Search Results

Overview

Uniprot ID	O75691
Protein Name	Small subunit processome component 20 homolog
Gene Name	UTP20
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1811	EHKLVKSKVVNDEEV
2510	WNTKKTKKHLPEPVA
2731	RALRKKRKALEFVTN
2744	TNPDIAAKKKMKKHK
2745	NPDIAAKKKMKKHKN
2760	KSEAKKRKIEFLRPG
9	KTKPVSHKTENTYRF

Function

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA

Protein Sequence

10 MKTKPVSHKT 20 ENTYRFLTFA 30 ERLGNVNIDI 40 IHRIDRTASY 50 EEEVETYFFE 60 GLLKWRELNL 70 TEHFGKFYKE 80 VIDKCQSFNQ 90 LVYHQNEIVQ 100 SLKTHLQVKN 110 SFAYQPLLDL 120 VVQLARDLQM 130 DFYPHFPEFF 140 LTITSILETQ 150 DTELLEWAFT 160 SLSYLYKYLW 170 RLMVKDMSSI 180 YSMYSTLLAH 190 KKLHIRNFAA 200 ESFTFLMRKV 210 SDKNALFNLM 220 FLDLDKHPEK 230 VEGVGQLLFE 240 MCKGVRNMFH 250 SCTGQAVKLI 260 LRKLGPVTET 270 ETQLPWMLIG 280 ETLKNMVKST 290 VSYISKEHFG 300 TFFECLQESL 310 LDLHTKVTKT 320 NCCESSEQIK 330 RLLETYLILV 340 KHGSGTKIPT 350 PADVCKVLSQ 360 TLQVASLSTS 370 CWETLLDVIS 380 ALILGENVSL 390 PETLIKETIE 400 KIFESRFEKR 410 LIFSFSEVMF 420 AMKQFEQLFL 430 PSFLSYIVNC 440 FLIDDAVVKD 450 EALAILAKLI 460 LNKAAPPTAG 470 SMAIEKYPLV 480 FSPQMVGFYI 490 KQKKTRSKGR 500 NEQFPVLDHL 510 LSIIKLPPNK 520 DTTYLSQSWA 530 ALVVLPHIRP 540 LEKEKVIPLV 550 TGFIEALFMT 560 VDKGSFGKGN 570 LFVLCQAVNT 580 LLSLEESSEL 590 LHLVPVERVK 600 NLVLTFPLEP 610 SVLLLTDLYY 620 QRLALCGCKG 630 PLSQEALMEL 640 FPKLQANIST 650 GVSKIRLLTI 660 RILNHFDVQL 670 PESMEDDGLS 680 ERQSVFAILR 690 QAELVPATVN 700 DYREKLLHLR 710 KLRHDVVQTA 720 VPDGPLQEVP 730 LRYLLGMLYI 740 NFSALWDPVI 750 ELISSHAHEM 760 ENKQFWKVYY 770 EHLEKAATHA 780 EKELQNDMTD 790 EKSVGDESWE 800 QTQEGDVGAL 810 YHEQLALKTD 820 CQERLDHTNF 830 RFLLWRALTK 840 FPERVEPRSR 850 ELSPLFLRFI 860 NNEYYPADLQ 870 VAPTQDLRRK 880 GKGMVAEEIE 890 EEPAAGDDEE 900 LEEEAVPQDE 910 SSQKKKTRRA 920 AAKQLIAHLQ 930 VFSKFSNPRA 940 LYLESKLYEL 950 YLQLLLHQDQ 960 MVQKITLDCI 970 MTYKHPHVLP 980 YRENLQRLLE 990 DRSFKEEIVH 1000 FSISEDNAVV 1010 KTAHRADLFP 1020 ILMRILYGRM 1030 KNKTGSKTQG 1040 KSASGTRMAI 1050 VLRFLAGTQP 1060 EEIQIFLDLL 1070 FEPVRHFKNG 1080 ECHSAVIQAV 1090 EDLDLSKVLP 1100 LGRQHGILNS 1110 LEIVLKNISH 1120 LISAYLPKIL 1130 QILLCMTATV 1140 SHILDQREKI 1150 QLRFINPLKN 1160 LRRLGIKMVT 1170 DIFLDWESYQ 1180 FRTEEIDAVF 1190 HGAVWPQISR 1200 LGSESQYSPT 1210 PLLKLISIWS 1220 RNARYFPLLA 1230 KQKPGHPECD 1240 ILTNVFAILS 1250 AKNLSDATAS 1260 IVMDIVDDLL 1270 NLPDFEPTET 1280 VLNLLVTGCV 1290 YPGIAENIGE 1300 SITIGGRLIL 1310 PHVPAILQYL 1320 SKTTISAEKV 1330 KKKKNRAQVS 1340 KELGILSKIS 1350 KFMKDKEQSS 1360 VLITLLLPFL 1370 HRGNIAEDTE 1380 VDILVTVQNL 1390 LKHCVDPTSF 1400 LKPIAKLFSV 1410 IKNKLSRKLL 1420 CTVFETLSDF 1430 ESGLKYITDV 1440 VKLNAFDQRH 1450 LDDINFDVRF 1460 ETFQTITSYI 1470 KEMQIVDVNY 1480 LIPVMHNCFY 1490 NLELGDMSLS 1500 DNASMCLMSI 1510 IKKLAALNVT 1520 EKDYREIIHR 1530 SLLEKLRKGL 1540 KSQTESIQQD 1550 YTTILSCLIQ 1560 TFPNQLEFKD 1570 LVQLTHYHDP 1580 EMDFFENMKH 1590 IQIHRRARAL 1600 KKLAKQLMEG 1610 KVVLSSKSLQ 1620 NYIMPYAMTP 1630 IFDEKMLKHE 1640 NITTAATEII 1650 GAICKHLSWS 1660 AYMYYLKHFI 1670 HVLQTGQINQ 1680 KLGVSLLVIV 1690 LEAFHFDHKT 1700 LEEQMGKIEN 1710 EENAIEAIEL 1720 PEPEAMELER 1730 VDEEEKEYTC 1740 KSLSDNGQPG 1750 TPDPADSGGT 1760 SAKESECITK 1770 PVSFLPQNKE 1780 EIERTIKNIQ 1790 GTITGDILPR 1800 LHKCLASTTK 1810 REEEHKLVKS 1820 KVVNDEEVVR 1830 VPLAFAMVKL 1840 MQSLPQEVME 1850 ANLPSILLKV 1860 CALLKNRAQE 1870 IRDIARSTLA 1880 KIIEDLGVHF 1890 LLYVLKELQT 1900 TLVRGYQVHV 1910 LTFTVHMLLQ 1920 GLTNKLQVGD 1930 LDSCLDIMIE 1940 IFNHELFGAV 1950 AEEKEVKQIL 1960 SKVMEARRSK 1970 SYDSYEILGK 1980 FVGKDQVTKL 1990 ILPLKEILQN 2000 TTSLKLARKV 2010 HETLRRITVG 2020 LIVNQEMTAE 2030 SILLLSYGLI 2040 SENLPLLTEK 2050 EKNPVAPAPD 2060 PRLPPQSCLL 2070 LPPTPVRGGQ 2080 KAVVSRKTNM 2090 HIFIESGLRL 2100 LHLSLKTSKI 2110 KSSGECVLEM 2120 LDPFVSLLID 2130 CLGSMDVKVI 2140 TGALQCLIWV 2150 LRFPLPSIET 2160 KAEQLTKHLF 2170 LLLKDYAKLG 2180 AARGQNFHLV 2190 VNCFKCVTIL 2200 VKKVKSYQIT 2210 EKQLQVLLAY 2220 AEEDIYDTSR 2230 QATAFGLLKA 2240 ILSRKLLVPE 2250 IDEVMRKVSK 2260 LAVSAQSEPA 2270 RVQCRQVFLK 2280 YILDYPLGDK 2290 LRPNLEFMLA 2300 QLNYEHETGR 2310 ESTLEMIAYL 2320 FDTFPQGLLH 2330 ENCGMFFIPL 2340 CLMTINDDSA 2350 TCKKMASMTI 2360 KSLLGKISLE 2370 KKDWLFDMVT 2380 TWFGAKKRLN 2390 RQLAALICGL 2400 FVESEGVDFE 2410 KRLGTVLPVI 2420 EKEIDPENFK 2430 DIMEETEEKA 2440 ADRLLFSFLT 2450 LITKLIKECN 2460 IIQFTKPAET 2470 LSKIWSHVHS 2480 HLRHPHNWVW 2490 LTAAQIFGLL 2500 FASCQPEELI 2510 QKWNTKKTKK 2520 HLPEPVAIKF 2530 LASDLDQKMK 2540 SISLASCHQL 2550 HSKFLDQSLG 2560 EQVVKNLLFA 2570 AKVLYLLELY 2580 CEDKQSKIKE 2590 DLEEQEALED 2600 GVACADEKAE 2610 SDGEEKEEVK 2620 EELGRPATLL 2630 WLIQKLSRIA 2640 KLEAAYSPRN 2650 PLKRTCIFKF 2660 LGAVAMDLGI 2670 DKVKPYLPMI 2680 IAPLFRELNS 2690 TYSEQDPLLK 2700 NLSQEIIELL 2710 KKLVGLESFS 2720 LAFASVQKQA 2730 NEKRALRKKR 2740 KALEFVTNPD 2750 IAAKKKMKKH 2760 KNKSEAKKRK 2770 IEFLRPGYKA 2780 KRQKSHSLKD LAMVE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030686	90S preribosome
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0030688	preribosome, small subunit precursor
Cellular Component	GO:0032040	small-subunit processome
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process	GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process	GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process	GO:0030490	maturation of SSU-rRNA
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0042274	ribosomal small subunit biogenesis
Biological Process	GO:0006364	rRNA processing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.