Search Results

Overview

Uniprot ID	O75694
Protein Name	Nuclear pore complex protein Nup155
Gene Name	NUP155
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
740	GNPNTTAKVQQRLIG
997	PQSPSVPKKPGPPVL
998	QSPSVPKKPGPPVLS

Function

Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport

Protein Sequence

10 MPSSLLGAAM 20 PASTSAAALQ 30 EALENAGRLI 40 DRQLQEDRMY 50 PDLSELLMVS 60 APNNPTVSGM 70 SDMDYPLQGP 80 GLLSVPNLPE 90 ISSIRRVPLP 100 PELVEQFGHM 110 QCNCMMGVFP 120 PISRAWLTID 130 SDIFMWNYED 140 GGDLAYFDGL 150 SETILAVGLV 160 KPKAGIFQPH 170 VRHLLVLATP 180 VDIVILGLSY 190 ANLQTGSGVL 200 NDSLSGGMQL 210 LPDPLYSLPT 220 DNTYLLTITS 230 TDNGRIFLAG 240 KDGCLYEVAY 250 QAEAGWFSQR 260 CRKINHSKSS 270 LSFLVPSLLQ 280 FTFSEDDPIL 290 QIAIDNSRNI 300 LYTRSEKGVI 310 QVYDLGQDGQ 320 GMSRVASVSQ 330 NAIVSAAGNI 340 ARTIDRSVFK 350 PIVQIAVIEN 360 SESLDCQLLA 370 VTHAGVRLYF 380 STCPFRQPLA 390 RPNTLTLVHV 400 RLPPGFSASS 410 TVEKPSKVHR 420 ALYSKGILLM 430 AASENEDNDI 440 LWCVNHDTFP 450 FQKPMMETQM 460 TAGVDGHSWA 470 LSAIDELKVD 480 KIITPLNKDH 490 IPITDSPVVV 500 QQHMLPPKKF 510 VLLSAQGSLM 520 FHKLRPVDQL 530 RHLLVSNVGG 540 DGEEIERFFK 550 LHQEDQACAT 560 CLILACSTAA 570 CDREVSAWAT 580 RAFFRYGGEA 590 QMRFPTTLPP 600 PSNVGPILGS 610 PVYSSSPVPS 620 GSPYPNPSFL 630 GTPSHGIQPP 640 AMSTPVCALG 650 NPATQATNMS 660 CVTGPEIVYS 670 GKHNGICIYF 680 SRIMGNIWDA 690 SLVVERIFKS 700 GNREITAIES 710 SVPCQLLESV 720 LQELKGLQEF 730 LDRNSQFAGG 740 PLGNPNTTAK 750 VQQRLIGFMR 760 PENGNPQQMQ 770 QELQRKFHEA 780 QLSEKISLQA 790 IQQLVRKSYQ 800 ALALWKLLCE 810 HQFTIIVAEL 820 QKELQEQLKI 830 TTFKDLVIRD 840 KELTGALIAS 850 LINCYIRDNA 860 AVDGISLHLQ 870 DICPLLYSTD 880 DAICSKANEL 890 LQRSRQVQNK 900 TEKERMLRES 910 LKEYQKISNQ 920 VDLSNVCAQY 930 RQVRFYEGVV 940 ELSLTAAEKK 950 DPQGLGLHFY 960 KHGEPEEDIV 970 GLQAFQERLN 980 SYKCITDTLQ 990 ELVNQSKAAP 1000 QSPSVPKKPG 1010 PPVLSSDPNM 1020 LSNEEAGHHF 1030 EQMLKLSQRS 1040 KDELFSIALY 1050 NWLIQVDLAD 1060 KLLQVASPFL 1070 EPHLVRMAKV 1080 DQNRVRYMDL 1090 LWRYYEKNRS 1100 FSNAARVLSR 1110 LADMHSTEIS 1120 LQQRLEYIAR 1130 AILSAKSSTA 1140 ISSIAADGEF 1150 LHELEEKMEV 1160 ARIQLQIQET 1170 LQRQYSHHSS 1180 VQDAVSQLDS 1190 ELMDITKLYG 1200 EFADPFKLAE 1210 CKLAIIHCAG 1220 YSDPILVQTL 1230 WQDIIEKELS 1240 DSVTLSSSDR 1250 MHALSLKIVL 1260 LGKIYAGTPR 1270 FFPLDFIVQF 1280 LEQQVCTLNW 1290 DVGFVIQTMN 1300 EIGVPLPRLL 1310 EVYDQLFKSR 1320 DPFWNRMKKP 1330 LHLLDCIHVL 1340 LIRYVENPSQ 1350 VLNCERRRFT 1360 NLCLDAVCGY 1370 LVELQSMSSS 1380 VAVQAITGNF 1390 KSLQAKLERL H

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005635	nuclear envelope
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0044611	nuclear pore inner ring
Molecular Function	GO:0017056	structural constituent of nuclear pore
Biological Process	GO:0051028	mRNA transport
Biological Process	GO:0006998	nuclear envelope organization
Biological Process	GO:0006913	nucleocytoplasmic transport
Biological Process	GO:0006606	protein import into nucleus
Biological Process	GO:0036228	protein localization to nuclear inner membrane
Biological Process	GO:0006405	RNA export from nucleus
Biological Process	GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.