Search Results

Overview

Uniprot IDO75717
Protein NameWD repeat and HMG-box DNA-binding protein 1
Gene NameWDHD1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1108 KENLNLSKKQKPLDF
1109 ENLNLSKKQKPLDFS
1120 LDFSTNQKLSAFAFK
805 KYASRSRKLILAQKL
840 EEEDFRKKLNAGYSN
899 NSSDVSAKSGAVTFS
915 QGRVNPFKVSASSKE
941 NILDNMGKSSKKSTA
945 NMGKSSKKSTALSRT
962 NEKSPIIKPLIPKPK
971 LIPKPKPKQASAASY
981 SAASYFQKRNSQTNK
988 KRNSQTNKTEEVKEE

Function

Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork

Protein Sequence

10 MPATRKPMRY 20 GHTEGHTEVC 30 FDDSGSFIVT 40 CGSDGDVRIW 50 EDLDDDDPKF 60 INVGEKAYSC 70 ALKSGKLVTA 80 VSNNTIQVHT 90 FPEGVPDGIL 100 TRFTTNANHV 110 VFNGDGTKIA 120 AGSSDFLVKI 130 VDVMDSSQQK 140 TFRGHDAPVL 150 SLSFDPKDIF 160 LASASCDGSV 170 RVWQISDQTC 180 AISWPLLQKC 190 NDVINAKSIC 200 RLAWQPKSGK 210 LLAIPVEKSV 220 KLYRRESWSH 230 QFDLSDNFIS 240 QTLNIVTWSP 250 CGQYLAAGSI 260 NGLIIVWNVE 270 TKDCMERVKH 280 EKGYAICGLA 290 WHPTCGRISY 300 TDAEGNLGLL 310 ENVCDPSGKT 320 SSSKVSSRVE 330 KDYNDLFDGD 340 DMSNAGDFLN 350 DNAVEIPSFS 360 KGIINDDEDD 370 EDLMMASGRP 380 RQRSHILEDD 390 ENSVDISMLK 400 TGSSLLKEEE 410 EDGQEGSIHN 420 LPLVTSQRPF 430 YDGPMPTPRQ 440 KPFQSGSTPL 450 HLTHRFMVWN 460 SIGIIRCYND 470 EQDNAIDVEF 480 HDTSIHHATH 490 LSNTLNYTIA 500 DLSHEAILLA 510 CESTDELASK 520 LHCLHFSSWD 530 SSKEWIIDLP 540 QNEDIEAICL 550 GQGWAAAATS 560 ALLLRLFTIG 570 GVQKEVFSLA 580 GPVVSMAGHG 590 EQLFIVYHRG 600 TGFDGDQCLG 610 VQLLELGKKK 620 KQILHGDPLP 630 LTRKSYLAWI 640 GFSAEGTPCY 650 VDSEGIVRML 660 NRGLGNTWTP 670 ICNTREHCKG 680 KSDHYWVVGI 690 HENPQQLRCI 700 PCKGSRFPPT 710 LPRPAVAILS 720 FKLPYCQIAT 730 EKGQMEEQFW 740 RSVIFHNHLD 750 YLAKNGYEYE 760 ESTKNQATKE 770 QQELLMKMLA 780 LSCKLEREFR 790 CVELADLMTQ 800 NAVNLAIKYA 810 SRSRKLILAQ 820 KLSELAVEKA 830 AELTATQVEE 840 EEEEEDFRKK 850 LNAGYSNTAT 860 EWSQPRFRNQ 870 VEEDAEDSGE 880 ADDEEKPEIH 890 KPGQNSFSKS 900 TNSSDVSAKS 910 GAVTFSSQGR 920 VNPFKVSASS 930 KEPAMSMNSA 940 RSTNILDNMG 950 KSSKKSTALS 960 RTTNNEKSPI 970 IKPLIPKPKP 980 KQASAASYFQ 990 KRNSQTNKTE 1000 EVKEENLKNV 1010 LSETPAICPP 1020 QNTENQRPKT 1030 GFQMWLEENR 1040 SNILSDNPDF 1050 SDEADIIKEG 1060 MIRFRVLSTE 1070 ERKVWANKAK 1080 GETASEGTEA 1090 KKRKRVVDES 1100 DETENQEEKA 1110 KENLNLSKKQ 1120 KPLDFSTNQK LSAFAFKQE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0043596 nuclear replication fork
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Biological Process GO:0006281 DNA repair
Biological Process GO:0006261 DNA-templated DNA replication
Biological Process GO:0000278 mitotic cell cycle

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.