Search Results
Overview
| Uniprot ID | O75781 |
|---|---|
| Protein Name | Paralemmin-1 |
| Gene Name | PALM |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 127 | APAPSPAKEERKTEV |
| 147 | QTPVGTPKDKRVSNT |
| 21 | RLQAIAEKRKRQAEI |
| 93 | DSVSRLEKEIEVLER |
Function
Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner
Protein Sequence
10
MEVLAAETTS
20
QQERLQAIAE
30
KRKRQAEIEN
40
KRRQLEDERR
50
QLQHLKSKAL
60
RERWLLEGTP
70
SSASEGDEDL
80
RRQMQDDEQK
90
TRLLEDSVSR
100
LEKEIEVLER
110
GDSAPATAKE
120
NAAAPSPVRA
130
PAPSPAKEER
140
KTEVVMNSQQ
150
TPVGTPKDKR
160
VSNTPLRTVD
170
GSPMMKAAMY
180
SVEITVEKDK
190
VTGETRVLSS
200
TTLLPRQPLP
210
LGIKVYEDET
220
KVVHAVDGTA
230
ENGIHPLSSS
240
EVDELIHKAD
250
EVTLSEAGST
260
AGAAETRGAV
270
EGAARTTPSR
280
REITGVQAQP
290
GEATSGPPGI
300
QPGQEPPVTM
310
IFMGYQNVED
320
EAETKKVLGL
330
QDTITAELVV
340
IEDAAEPKEP
350
APPNGSAAEP
360
PTEAASREEN
370
QAGPEATTSD
380
PQDLDMKKHR
CKCCSIM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016327 | apicolateral plasma membrane |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0031527 | filopodium membrane |
| Cellular Component | GO:0044309 | neuron spine |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0097060 | synaptic membrane |
| Molecular Function | GO:0031750 | D3 dopamine receptor binding |
| Biological Process | GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| Biological Process | GO:0071257 | cellular response to electrical stimulus |
| Biological Process | GO:0060160 | negative regulation of dopamine receptor signaling pathway |
| Biological Process | GO:0051491 | positive regulation of filopodium assembly |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:0060074 | synapse maturation |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.