Search Results
Overview
| Uniprot ID | O75792 |
|---|---|
| Protein Name | Ribonuclease H2 subunit A |
| Gene Name | RNASEH2A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 267 | ENQEGLRKITSYFLN |
Function
Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes
Protein Sequence
10
MDLSELERDN
20
TGRCRLSSPV
30
PAVCRKEPCV
40
LGVDEAGRGP
50
VLGPMVYAIC
60
YCPLPRLADL
70
EALKVADSKT
80
LLESERERLF
90
AKMEDTDFVG
100
WALDVLSPNL
110
ISTSMLGRVK
120
YNLNSLSHDT
130
ATGLIQYALD
140
QGVNVTQVFV
150
DTVGMPETYQ
160
ARLQQSFPGI
170
EVTVKAKADA
180
LYPVVSAASI
190
CAKVARDQAV
200
KKWQFVEKLQ
210
DLDTDYGSGY
220
PNDPKTKAWL
230
KEHVEPVFGF
240
PQFVRFSWRT
250
AQTILEKEAE
260
DVIWEDSASE
270
NQEGLRKITS
280
YFLNEGSQAR
290
PRSSHRYFLE
RGLESATSL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0032299 | ribonuclease H2 complex |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0004540 | RNA nuclease activity |
| Molecular Function | GO:0004523 | RNA-DNA hybrid ribonuclease activity |
| Biological Process | GO:0006260 | DNA replication |
| Biological Process | GO:0043137 | DNA replication, removal of RNA primer |
| Biological Process | GO:0006298 | mismatch repair |
| Biological Process | GO:0006401 | RNA catabolic process |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.