Overview
| Uniprot ID | O75795 |
|---|
| Protein Name | UDP-glucuronosyltransferase 2B17 |
|---|
| Gene Name | UGT2B17 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 135 |
CEDAVLNKKLMRKLQ |
| 440 |
VINDPIYKENIMKLS |
| 445 |
IYKENIMKLSRIHHD |
Function
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:16595710, PubMed:18719240, PubMed:19022937, PubMed:23288867, PubMed:8798464). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol) (PubMed:16595710, PubMed:18719240, PubMed:19022937, PubMed:23288867, PubMed:8798464)
Protein Sequence
10
MSLKWMSVFL
20
LMQLSCYFSS
30
GSCGKVLVWP
40
TEYSHWINMK
50
TILEELVQRG
60
HEVIVLTSSA
70
SILVNASKSS
80
AIKLEVYPTS
90
LTKNDLEDFF
100
MKMFDRWTYS
110
ISKNTFWSYF
120
SQLQELCWEY
130
SDYNIKLCED
140
AVLNKKLMRK
150
LQESKFDVLL
160
ADAVNPCGEL
170
LAELLNIPFL
180
YSLRFSVGYT
190
VEKNGGGFLF
200
PPSYVPVVMS
210
ELSDQMIFME
220
RIKNMIYMLY
230
FDFWFQAYDL
240
KKWDQFYSEV
250
LGRPTTLFET
260
MGKAEMWLIR
270
TYWDFEFPRP
280
FLPNVDFVGG
290
LHCKPAKPLP
300
KEMEEFVQSS
310
GENGIVVFSL
320
GSMISNMSEE
330
SANMIASALA
340
QIPQKVLWRF
350
DGKKPNTLGS
360
NTRLYKWLPQ
370
NDLLGHPKTK
380
AFITHGGTNG
390
IYEAIYHGIP
400
MVGIPLFADQ
410
HDNIAHMKAK
420
GAALSVDIRT
430
MSSRDLLNAL
440
KSVINDPIYK
450
ENIMKLSRIH
460
HDQPVKPLDR
470
AVFWIEFVMR
480
HKGAKHLRVA
490
AHNLTWIQYH
500
SLDVIAFLLA
510
CVATMIFMIT
520
KCCLFCFRKL
530
AKTGKKKKRD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Molecular Function |
GO:0015020 |
glucuronosyltransferase activity |
| Biological Process |
GO:0008210 |
estrogen metabolic process |
| Biological Process |
GO:0008202 |
steroid metabolic process |
| Biological Process |
GO:0006805 |
xenobiotic metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.