Search Results

Overview

Uniprot IDO75815
Protein NameBreast cancer anti-estrogen resistance protein 3
Gene NameBCAR3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
347 SYLPIGCKLPPQSSG
56 GTLPRKKKGPPPIRS

Function

Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (PubMed:24216110). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1 (PubMed:19086031). Inhibits cell migration and invasion via regulation of TGFB-mediated matrix digestion, actin filament rearrangement, and inhibition of invadopodia activity (By similarity). May inhibit TGFB-SMAD signaling, via facilitating BCAR1 and SMAD2 and/or SMAD3 interaction (By similarity). Regulates EGF-induced DNA synthesis (PubMed:18722344). Required for the maintenance of ocular lens morphology and structural integrity, potentially via regulation of focal adhesion complex signaling (By similarity). Acts upstream of PTPRA to regulate the localization of BCAR1 and PTPRA to focal adhesions, via regulation of SRC-mediated phosphorylation of PTPRA (By similarity). Positively regulates integrin-induced tyrosine phosphorylation of BCAR1 (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for small GTPases RALA, RAP1A and RRAS (By similarity). However, in a contrasting study, lacks GEF activity towards RAP1 (PubMed:22081014)

Protein Sequence

10 MAAGKFASLP 20 RNMPVNHQFP 30 LASSMDLLSS 40 RSPLAEHRPD 50 AYQDVSIHGT 60 LPRKKKGPPP 70 IRSCDDFSHM 80 GTLPHSKSPR 90 QNSPVTQDGI 100 QESPWQDRHG 110 ETFTFRDPHL 120 LDPTVEYVKF 130 SKERHIMDRT 140 PEKLKKELEE 150 ELLLSSEDLR 160 SHAWYHGRIP 170 RQVSENLVQR 180 DGDFLVRDSL 190 SSPGNFVLTC 200 QWKNLAQHFK 210 INRTVLRLSE 220 AYSRVQYQFE 230 MESFDSIPGL 240 VRCYVGNRRP 250 ISQQSGAIIF 260 QPINRTVPLR 270 CLEEHYGTSP 280 GQAREGSLTK 290 GRPDVAKRLS 300 LTMGGVQARE 310 QNLPRGNLLR 320 NKEKSGSQPA 330 CLDHMQDRRA 340 LSLKAHQSES 350 YLPIGCKLPP 360 QSSGVDTSPC 370 PNSPVFRTGS 380 EPALSPAVVR 390 RVSSDARAGE 400 ALRGSDSQLC 410 PKPPPKPCKV 420 PFLKVPSSPS 430 AWLNSEANYC 440 ELNPAFATGC 450 GRGAKLPSCA 460 QGSHTELLTA 470 KQNEAPGPRN 480 SGVNYLILDD 490 DDRERPWEPA 500 AAQMEKGQWD 510 KGEFVTPLLE 520 TVSSFRPNEF 530 ESKFLPPENK 540 PLETAMLKRA 550 KELFTNNDPK 560 VIAQHVLSMD 570 CRVARILGVS 580 EEMRRNMGVS 590 SGLELITLPH 600 GHQLRLDIIE 610 RHNTMAIGIA 620 VDILGCTGTL 630 EDRAATLSKI 640 IQVAVELKDS 650 MGDLYSFSAL 660 MKALEMPQIT 670 RLEKTWTALR 680 HQYTQTAILY 690 EKQLKPFSKL 700 LHEGRESTCV 710 PPNNVSVPLL 720 MPLVTLMERQ 730 AVTFEGTDMW 740 EKNDQSCEIM 750 LNHLATARFM 760 AEAADSYRMN 770 AERILAGFQP 780 DEEMNEICKT 790 EFQMRLLWGS 800 KGAQVNQTER 810 YEKFNQILTA 820 LSRKLEPPPV KQAEL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0016020 membrane
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0019900 kinase binding
Molecular Function GO:0001784 phosphotyrosine residue binding
Biological Process GO:0086100 endothelin receptor signaling pathway
Biological Process GO:0007173 epidermal growth factor receptor signaling pathway
Biological Process GO:0008286 insulin receptor signaling pathway
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0009410 response to xenobiotic stimulus
Biological Process GO:0007165 signal transduction
Biological Process GO:0007264 small GTPase-mediated signal transduction

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.