Search Results
Overview
| Uniprot ID | O75828 |
|---|---|
| Protein Name | Carbonyl reductase [NADPH] 3 |
| Gene Name | CBR3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 238 | VKTDMDGKDSIRTVE |
Function
Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols (PubMed:18493841). Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin (PubMed:15537833, PubMed:18493841, PubMed:19841672). Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones (PubMed:19841672). Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified (PubMed:19841672)
Protein Sequence
10
MSSCSRVALV
20
TGANRGIGLA
30
IARELCRQFS
40
GDVVLTARDV
50
ARGQAAVQQL
60
QAEGLSPRFH
70
QLDIDDLQSI
80
RALRDFLRKE
90
YGGLNVLVNN
100
AAVAFKSDDP
110
MPFDIKAEMT
120
LKTNFFATRN
130
MCNELLPIMK
140
PHGRVVNISS
150
LQCLRAFENC
160
SEDLQERFHS
170
ETLTEGDLVD
180
LMKKFVEDTK
190
NEVHEREGWP
200
NSPYGVSKLG
210
VTVLSRILAR
220
RLDEKRKADR
230
ILVNACCPGP
240
VKTDMDGKDS
250
IRTVEEGAET
260
PVYLALLPPD
270
ATEPQGQLVH
DKVVQNW
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0000253 | 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity |
| Molecular Function | GO:0004090 | carbonyl reductase (NADPH) activity |
| Molecular Function | GO:0070402 | NADPH binding |
| Molecular Function | GO:0008753 | NADPH dehydrogenase (quinone) activity |
| Biological Process | GO:0050890 | cognition |
| Biological Process | GO:0042376 | phylloquinone catabolic process |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
Reference
PMID: N/A