Search Results

Overview

Uniprot ID	O75844
Protein Name	CAAX prenyl protease 1 homolog
Gene Name	ZMPSTE24
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
429	AKKLGKAKDLYSALI

Function

Transmembrane metalloprotease whose catalytic activity is critical for processing lamin A/LMNA on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum (PubMed:33293369, PubMed:33315887). Proteolytically removes the C-terminal three residues of farnesylated proteins (PubMed:33293369, PubMed:33315887). Also plays an antiviral role independently of its protease activity by restricting enveloped RNA and DNA viruses, including influenza A, Zika, Ebola, Sindbis, vesicular stomatitis, cowpox, and vaccinia (PubMed:28169297, PubMed:28246125). Mechanistically, controls IFITM antiviral pathway to hinder viruses from breaching the endosomal barrier by modulating membrane fluidity (PubMed:35283811)

Protein Sequence

10 MGMWASLDAL 20 WEMPAEKRIF 30 GAVLLFSWTV 40 YLWETFLAQR 50 QRRIYKTTTH 60 VPPELGQIMD 70 SETFEKSRLY 80 QLDKSTFSFW 90 SGLYSETEGT 100 LILLFGGIPY 110 LWRLSGRFCG 120 YAGFGPEYEI 130 TQSLVFLLLA 140 TLFSALTGLP 150 WSLYNTFVIE 160 EKHGFNQQTL 170 GFFMKDAIKK 180 FVVTQCILLP 190 VSSLLLYIIK 200 IGGDYFFIYA 210 WLFTLVVSLV 220 LVTIYADYIA 230 PLFDKFTPLP 240 EGKLKEEIEV 250 MAKSIDFPLT 260 KVYVVEGSKR 270 SSHSNAYFYG 280 FFKNKRIVLF 290 DTLLEEYSVL 300 NKDIQEDSGM 310 EPRNEEEGNS 320 EEIKAKVKNK 330 KQGCKNEEVL 340 AVLGHELGHW 350 KLGHTVKNII 360 ISQMNSFLCF 370 FLFAVLIGRK 380 ELFAAFGFYD 390 SQPTLIGLLI 400 IFQFIFSPYN 410 EVLSFCLTVL 420 SRRFEFQADA 430 FAKKLGKAKD 440 LYSALIKLNK 450 DNLGFPVSDW 460 LFSMWHYSHP 470 PLLERLQALK TMKQH

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0031901	early endosome membrane
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0031902	late endosome membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005637	nuclear inner membrane
Cellular Component	GO:0032991	protein-containing complex
Molecular Function	GO:0003690	double-stranded DNA binding
Molecular Function	GO:0004175	endopeptidase activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004222	metalloendopeptidase activity
Molecular Function	GO:0008235	metalloexopeptidase activity
Biological Process	GO:0071586	CAAX-box protein processing
Biological Process	GO:0006998	nuclear envelope organization
Biological Process	GO:0051604	protein maturation
Biological Process	GO:0006508	proteolysis
Biological Process	GO:0050688	regulation of defense response to virus

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.