Search Results

Overview

Uniprot IDO75891
Protein NameCytosolic 10-formyltetrahydrofolate dehydrogenase
Gene NameALDH1L1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
128 WTLIHGDKKGGFSIF
187 VRLIAEGKAPRLPQP
21 EVYCHLRKEGHEVVG
229 NWIRGNDKVPGAWTE
290 DDKMLLVKNIQLEDG
469 DKAVAAAKDAFENGR
615 KFAELTLKAGIPKGV
62 KYSRWRAKGQALPDV
645 SDHPDVRKIGFTGST
656 TGSTEVGKHIMKSCA
660 EVGKHIMKSCAISNV
668 SCAISNVKKVSLELG
669 CAISNVKKVSLELGG
735 VEEVRKMKVGNPLDR
767 EYCQHGVKEGATLVC

Function

Cytosolic 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide (PubMed:19933275, PubMed:21238436). May also have an NADP(+)-dependent aldehyde dehydrogenase activity towards formaldehyde, acetaldehyde, propionaldehyde, and benzaldehyde (By similarity)

Protein Sequence

10 MKIAVIGQSL 20 FGQEVYCHLR 30 KEGHEVVGVF 40 TVPDKDGKAD 50 PLGLEAEKDG 60 VPVFKYSRWR 70 AKGQALPDVV 80 AKYQALGAEL 90 NVLPFCSQFI 100 PMEIISAPRH 110 GSIIYHPSLL 120 PRHRGASAIN 130 WTLIHGDKKG 140 GFSIFWADDG 150 LDTGDLLLQK 160 ECEVLPDDTV 170 STLYNRFLFP 180 EGIKGMVQAV 190 RLIAEGKAPR 200 LPQPEEGATY 210 EGIQKKETAK 220 INWDQPAEAI 230 HNWIRGNDKV 240 PGAWTEACEQ 250 KLTFFNSTLN 260 TSGLVPEGDA 270 LPIPGAHRPG 280 VVTKAGLILF 290 GNDDKMLLVK 300 NIQLEDGKMI 310 LASNFFKGAA 320 SSVLELTEAE 330 LVTAEAVRSV 340 WQRILPKVLE 350 VEDSTDFFKS 360 GAASVDVVRL 370 VEEVKELCDG 380 LELENEDVYM 390 ASTFGDFIQL 400 LVRKLRGDDE 410 EGECSIDYVE 420 MAVNKRTVRM 430 PHQLFIGGEF 440 VDAEGAKTSE 450 TINPTDGSVI 460 CQVSLAQVTD 470 VDKAVAAAKD 480 AFENGRWGKI 490 SARDRGRLMY 500 RLADLMEQHQ 510 EELATIEALD 520 AGAVYTLALK 530 THVGMSIQTF 540 RYFAGWCDKI 550 QGSTIPINQA 560 RPNRNLTLTR 570 KEPVGVCGII 580 IPWNYPLMML 590 SWKTAACLAA 600 GNTVVIKPAQ 610 VTPLTALKFA 620 ELTLKAGIPK 630 GVVNVLPGSG 640 SLVGQRLSDH 650 PDVRKIGFTG 660 STEVGKHIMK 670 SCAISNVKKV 680 SLELGGKSPL 690 IIFADCDLNK 700 AVQMGMSSVF 710 FNKGENCIAA 720 GRLFVEDSIH 730 DEFVRRVVEE 740 VRKMKVGNPL 750 DRDTDHGPQN 760 HHAHLVKLME 770 YCQHGVKEGA 780 TLVCGGNQVP 790 RPGFFFEPTV 800 FTDVEDHMFI 810 AKEESFGPVM 820 IISRFADGDL 830 DAVLSRANAT 840 EFGLASGVFT 850 RDINKALYVS 860 DKLQAGTVFV 870 NTYNKTDVAA 880 PFGGFKQSGF 890 GKDLGEAALN 900 EYLRVKTVTF EY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0004029 aldehyde dehydrogenase (NAD+) activity
Molecular Function GO:0016155 formyltetrahydrofolate dehydrogenase activity
Biological Process GO:0009258 10-formyltetrahydrofolate catabolic process
Biological Process GO:0006740 NADPH regeneration
Biological Process GO:0035999 tetrahydrofolate interconversion

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.