Overview
| Uniprot ID | O75899 |
|---|
| Protein Name | Gamma-aminobutyric acid type B receptor subunit 2 |
|---|
| Gene Name | GABBR2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 768 |
QFTQNQKKEDSKTST |
Function
Component of a heterodimeric G protein-coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054, PubMed:9872316, PubMed:9872744). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:10773016, PubMed:10906333, PubMed:9872744). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:22660477, PubMed:9872744). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:10075644, PubMed:22660477, PubMed:9872316, PubMed:9872744). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable)
Protein Sequence
10
MASPRSSGQP
20
GPPPPPPPPP
30
ARLLLLLLLP
40
LLLPLAPGAW
50
GWARGAPRPP
60
PSSPPLSIMG
70
LMPLTKEVAK
80
GSIGRGVLPA
90
VELAIEQIRN
100
ESLLRPYFLD
110
LRLYDTECDN
120
AKGLKAFYDA
130
IKYGPNHLMV
140
FGGVCPSVTS
150
IIAESLQGWN
160
LVQLSFAATT
170
PVLADKKKYP
180
YFFRTVPSDN
190
AVNPAILKLL
200
KHYQWKRVGT
210
LTQDVQRFSE
220
VRNDLTGVLY
230
GEDIEISDTE
240
SFSNDPCTSV
250
KKLKGNDVRI
260
ILGQFDQNMA
270
AKVFCCAYEE
280
NMYGSKYQWI
290
IPGWYEPSWW
300
EQVHTEANSS
310
RCLRKNLLAA
320
MEGYIGVDFE
330
PLSSKQIKTI
340
SGKTPQQYER
350
EYNNKRSGVG
360
PSKFHGYAYD
370
GIWVIAKTLQ
380
RAMETLHASS
390
RHQRIQDFNY
400
TDHTLGRIIL
410
NAMNETNFFG
420
VTGQVVFRNG
430
ERMGTIKFTQ
440
FQDSREVKVG
450
EYNAVADTLE
460
IINDTIRFQG
470
SEPPKDKTII
480
LEQLRKISLP
490
LYSILSALTI
500
LGMIMASAFL
510
FFNIKNRNQK
520
LIKMSSPYMN
530
NLIILGGMLS
540
YASIFLFGLD
550
GSFVSEKTFE
560
TLCTVRTWIL
570
TVGYTTAFGA
580
MFAKTWRVHA
590
IFKNVKMKKK
600
IIKDQKLLVI
610
VGGMLLIDLC
620
ILICWQAVDP
630
LRRTVEKYSM
640
EPDPAGRDIS
650
IRPLLEHCEN
660
THMTIWLGIV
670
YAYKGLLMLF
680
GCFLAWETRN
690
VSIPALNDSK
700
YIGMSVYNVG
710
IMCIIGAAVS
720
FLTRDQPNVQ
730
FCIVALVIIF
740
CSTITLCLVF
750
VPKLITLRTN
760
PDAATQNRRF
770
QFTQNQKKED
780
SKTSTSVTSV
790
NQASTSRLEG
800
LQSENHRLRM
810
KITELDKDLE
820
EVTMQLQDTP
830
EKTTYIKQNH
840
YQELNDILNL
850
GNFTESTDGG
860
KAILKNHLDQ
870
NPQLQWNTTE
880
PSRTCKDPIE
890
DINSPEHIQR
900
RLSLQLPILH
910
HAYLPSIGGV
920
DASCVSPCVS
930
PTASPRHRHV
940
PPSFRVMVSG
L
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0038039 |
G protein-coupled receptor heterodimeric complex |
| Cellular Component |
GO:1902710 |
GABA receptor complex |
| Cellular Component |
GO:0043005 |
neuron projection |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0045211 |
postsynaptic membrane |
| Molecular Function |
GO:0004965 |
G protein-coupled GABA receptor activity |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0004888 |
transmembrane signaling receptor activity |
| Biological Process |
GO:0007193 |
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| Biological Process |
GO:0007268 |
chemical synaptic transmission |
| Biological Process |
GO:0007186 |
G protein-coupled receptor signaling pathway |
| Biological Process |
GO:0007214 |
gamma-aminobutyric acid signaling pathway |
| Biological Process |
GO:0007194 |
negative regulation of adenylate cyclase activity |
| Biological Process |
GO:0150099 |
neuron-glial cell signaling |
| Biological Process |
GO:0051932 |
synaptic transmission, GABAergic |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.