Search Results
Overview
| Uniprot ID | O75909 |
|---|---|
| Protein Name | Cyclin-K |
| Gene Name | CCNK |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 354 | AAEPPPPKIPKIETT |
Function
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A)
Protein Sequence
10
MKENKENSSP
20
SVTSANLDHT
30
KPCWYWDKKD
40
LAHTPSQLEG
50
LDPATEARYR
60
REGARFIFDV
70
GTRLGLHYDT
80
LATGIIYFHR
90
FYMFHSFKQF
100
PRYVTGACCL
110
FLAGKVEETP
120
KKCKDIIKTA
130
RSLLNDVQFG
140
QFGDDPKEEV
150
MVLERILLQT
160
IKFDLQVEHP
170
YQFLLKYAKQ
180
LKGDKNKIQK
190
LVQMAWTFVN
200
DSLCTTLSLQ
210
WEPEIIAVAV
220
MYLAGRLCKF
230
EIQEWTSKPM
240
YRRWWEQFVQ
250
DVPVDVLEDI
260
CHQILDLYSQ
270
GKQQMPHHTP
280
HQLQQPPSLQ
290
PTPQVPQVQQ
300
SQPSQSSEPS
310
QPQQKDPQQP
320
AQQQQPAQQP
330
KKPSPQPSSP
340
RQVKRAVVVS
350
PKEENKAAEP
360
PPPKIPKIET
370
THPPLPPAHP
380
PPDRKPPLAA
390
ALGEAEPPGP
400
VDATDLPKVQ
410
IPPPAHPAPV
420
HQPPPLPHRP
430
PPPPPSSYMT
440
GMSTTSSYMS
450
GEGYQSLQSM
460
MKTEGPSYGA
470
LPPAYGPPAH
480
LPYHPHVYPP
490
NPPPPPVPPP
500
PASFPPPAIP
510
PPTPGYPPPP
520
PTYNPNFPPP
530
PPRLPPTHAV
540
PPHPPPGLGL
550
PPASYPPPAV
560
PPGGQPPVPP
570
PIPPPGMPPV
580
GGLGRAAWMR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0002944 | cyclin K-CDK12 complex |
| Cellular Component | GO:0002945 | cyclin K-CDK13 complex |
| Cellular Component | GO:0008024 | cyclin/CDK positive transcription elongation factor complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity |
| Molecular Function | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0008353 | RNA polymerase II CTD heptapeptide repeat kinase activity |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0044828 | host-mediated suppression of viral genome replication |
| Biological Process | GO:0032786 | positive regulation of DNA-templated transcription, elongation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032968 | positive regulation of transcription elongation by RNA polymerase II |
| Biological Process | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| Biological Process | GO:0009966 | regulation of signal transduction |
| Biological Process | GO:0006366 | transcription by RNA polymerase II |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.