Overview
| Uniprot ID | O75914 |
|---|
| Protein Name | Serine/threonine-protein kinase PAK 3 |
|---|
| Gene Name | PAK3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 260 |
DRQRKKSKMTDEEIL |
Function
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity)
Protein Sequence
10
MSDGLDNEEK
20
PPAPPLRMNS
30
NNRDSSALNH
40
SSKPLPMAPE
50
EKNKKARLRS
60
IFPGGGDKTN
70
KKKEKERPEI
80
SLPSDFEHTI
90
HVGFDAVTGE
100
FTPDLYGSQM
110
CPGKLPEGIP
120
EQWARLLQTS
130
NITKLEQKKN
140
PQAVLDVLKF
150
YDSKETVNNQ
160
KYMSFTSGDK
170
SAHGYIAAHP
180
SSTKTASEPP
190
LAPPVSEEED
200
EEEEEEEDEN
210
EPPPVIAPRP
220
EHTKSIYTRS
230
VVESIASPAV
240
PNKEVTPPSA
250
ENANSSTLYR
260
NTDRQRKKSK
270
MTDEEILEKL
280
RSIVSVGDPK
290
KKYTRFEKIG
300
QGASGTVYTA
310
LDIATGQEVA
320
IKQMNLQQQP
330
KKELIINEIL
340
VMRENKNPNI
350
VNYLDSYLVG
360
DELWVVMEYL
370
AGGSLTDVVT
380
ETCMDEGQIA
390
AVCRECLQAL
400
DFLHSNQVIH
410
RDIKSDNILL
420
GMDGSVKLTD
430
FGFCAQITPE
440
QSKRSTMVGT
450
PYWMAPEVVT
460
RKAYGPKVDI
470
WSLGIMAIEM
480
VEGEPPYLNE
490
NPLRALYLIA
500
TNGTPELQNP
510
ERLSAVFRDF
520
LNRCLEMDVD
530
RRGSAKELLQ
540
HPFLKLAKPL
550
SSLTPLIIAA
KEAIKNSSR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0014069 |
postsynaptic density |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0004708 |
MAP kinase kinase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0106310 |
protein serine kinase activity |
| Molecular Function |
GO:0004674 |
protein serine/threonine kinase activity |
| Molecular Function |
GO:0017124 |
SH3 domain binding |
| Molecular Function |
GO:0031267 |
small GTPase binding |
| Biological Process |
GO:0007409 |
axonogenesis |
| Biological Process |
GO:0016477 |
cell migration |
| Biological Process |
GO:0009267 |
cellular response to starvation |
| Biological Process |
GO:0016358 |
dendrite development |
| Biological Process |
GO:0060997 |
dendritic spine morphogenesis |
| Biological Process |
GO:0048013 |
ephrin receptor signaling pathway |
| Biological Process |
GO:0035556 |
intracellular signal transduction |
| Biological Process |
GO:0032956 |
regulation of actin cytoskeleton organization |
| Biological Process |
GO:0030833 |
regulation of actin filament polymerization |
| Biological Process |
GO:0050770 |
regulation of axonogenesis |
| Biological Process |
GO:0043408 |
regulation of MAPK cascade |
| Biological Process |
GO:0099175 |
regulation of postsynapse organization |
| Biological Process |
GO:0002223 |
stimulatory C-type lectin receptor signaling pathway |
| Biological Process |
GO:0050808 |
synapse organization |
Reference
PMID: N/A