Search Results

Overview

Uniprot IDO75915
Protein NamePRA1 family protein 3
Gene NameARL6IP5
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
151 LKNKLENKMEGIGLK
158 KMEGIGLKRTPMGIV
185 RLTDYISKVKE****
187 TDYISKVKE******

Function

Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum

Protein Sequence

10 MDVNIAPLRA 20 WDDFFPGSDR 30 FARPDFRDIS 40 KWNNRVVSNL 50 LYYQTNYLVV 60 AAMMISIVGF 70 LSPFNMILGG 80 IVVVLVFTGF 90 VWAAHNKDVL 100 RRMKKRYPTT 110 FVMVVMLASY 120 FLISMFGGVM 130 VFVFGITFPL 140 LLMFIHASLR 150 LRNLKNKLEN 160 KMEGIGLKRT 170 PMGIVLDALE 180 QQEEGINRLT DYISKVKE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0099523 presynaptic cytosol
Biological Process GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
Biological Process GO:0015813 L-glutamate transmembrane transport
Biological Process GO:0002037 negative regulation of L-glutamate import across plasma membrane
Biological Process GO:0010917 negative regulation of mitochondrial membrane potential
Biological Process GO:0051051 negative regulation of transport
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0032874 positive regulation of stress-activated MAPK cascade
Biological Process GO:0015031 protein transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.