Search Results

Overview

Uniprot IDO75923
Protein NameDysferlin
Gene NameDYSF
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
842 FLKYPMEKVPGARMP

Function

Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity)

Protein Sequence

10 MLRVFILYAE 20 NVHTPDTDIS 30 DAYCSAVFAG 40 VKKRTKVIKN 50 SVNPVWNEGF 60 EWDLKGIPLD 70 QGSELHVVVK 80 DHETMGRNRF 90 LGEAKVPLRE 100 VLATPSLSAS 110 FNAPLLDTKK 120 QPTGASLVLQ 130 VSYTPLPGAV 140 PLFPPPTPLE 150 PSPTLPDLDV 160 VADTGGEEDT 170 EDQGLTGDEA 180 EPFLDQSGGP 190 GAPTTPRKLP 200 SRPPPHYPGI 210 KRKRSAPTSR 220 KLLSDKPQDF 230 QIRVQVIEGR 240 QLPGVNIKPV 250 VKVTAAGQTK 260 RTRIHKGNSP 270 LFNETLFFNL 280 FDSPGELFDE 290 PIFITVVDSR 300 SLRTDALLGE 310 FRMDVGTIYR 320 EPRHAYLRKW 330 LLLSDPDDFS 340 AGARGYLKTS 350 LCVLGPGDEA 360 PLERKDPSED 370 KEDIESNLLR 380 PTGVALRGAH 390 FCLKVFRAED 400 LPQMDDAVMD 410 NVKQIFGFES 420 NKKNLVDPFV 430 EVSFAGKMLC 440 SKILEKTANP 450 QWNQNITLPA 460 MFPSMCEKMR 470 IRIIDWDRLT 480 HNDIVATTYL 490 SMSKISAPGG 500 EIEEEPAGAV 510 KPSKASDLDD 520 YLGFLPTFGP 530 CYINLYGSPR 540 EFTGFPDPYT 550 ELNTGKGEGV 560 AYRGRLLLSL 570 ETKLVEHSEQ 580 KVEDLPADDI 590 LRVEKYLRRR 600 KYSLFAAFYS 610 ATMLQDVDDA 620 IQFEVSIGNY 630 GNKFDMTCLP 640 LASTTQYSRA 650 VFDGCHYYYL 660 PWGNVKPVVV 670 LSSYWEDISH 680 RIETQNQLLG 690 IADRLEAGLE 700 QVHLALKAQC 710 STEDVDSLVA 720 QLTDELIAGC 730 SQPLGDIHET 740 PSATHLDQYL 750 YQLRTHHLSQ 760 ITEAALALKL 770 GHSELPAALE 780 QAEDWLLRLR 790 ALAEEPQNSL 800 PDIVIWMLQG 810 DKRVAYQRVP 820 AHQVLFSRRG 830 ANYCGKNCGK 840 LQTIFLKYPM 850 EKVPGARMPV 860 QIRVKLWFGL 870 SVDEKEFNQF 880 AEGKLSVFAE 890 TYENETKLAL 900 VGNWGTTGLT 910 YPKFSDVTGK 920 IKLPKDSFRP 930 SAGWTWAGDW 940 FVCPEKTLLH 950 DMDAGHLSFV 960 EEVFENQTRL 970 PGGQWIYMSD 980 NYTDVNGEKV 990 LPKDDIECPL 1000 GWKWEDEEWS 1010 TDLNRAVDEQ 1020 GWEYSITIPP 1030 ERKPKHWVPA 1040 EKMYYTHRRR 1050 RWVRLRRRDL 1060 SQMEALKRHR 1070 QAEAEGEGWE 1080 YASLFGWKFH 1090 LEYRKTDAFR 1100 RRRWRRRMEP 1110 LEKTGPAAVF 1120 ALEGALGGVM 1130 DDKSEDSMSV 1140 STLSFGVNRP 1150 TISCIFDYGN 1160 RYHLRCYMYQ 1170 ARDLAAMDKD 1180 SFSDPYAIVS 1190 FLHQSQKTVV 1200 VKNTLNPTWD 1210 QTLIFYEIEI 1220 FGEPATVAEQ 1230 PPSIVVELYD 1240 HDTYGADEFM 1250 GRCICQPSLE 1260 RMPRLAWFPL 1270 TRGSQPSGEL 1280 LASFELIQRE 1290 KPAIHHIPGF 1300 EVQETSRILD 1310 ESEDTDLPYP 1320 PPQREANIYM 1330 VPQNIKPALQ 1340 RTAIEILAWG 1350 LRNMKSYQLA 1360 NISSPSLVVE 1370 CGGQTVQSCV 1380 IRNLRKNPNF 1390 DICTLFMEVM 1400 LPREELYCPP 1410 ITVKVIDNRQ 1420 FGRRPVVGQC 1430 TIRSLESFLC 1440 DPYSAESPSP 1450 QGGPDDVSLL 1460 SPGEDVLIDI 1470 DDKEPLIPIQ 1480 EEEFIDWWSK 1490 FFASIGEREK 1500 CGSYLEKDFD 1510 TLKVYDTQLE 1520 NVEAFEGLSD 1530 FCNTFKLYRG 1540 KTQEETEDPS 1550 VIGEFKGLFK 1560 IYPLPEDPAI 1570 PMPPRQFHQL 1580 AAQGPQECLV 1590 RIYIVRAFGL 1600 QPKDPNGKCD 1610 PYIKISIGKK 1620 SVSDQDNYIP 1630 CTLEPVFGKM 1640 FELTCTLPLE 1650 KDLKITLYDY 1660 DLLSKDEKIG 1670 ETVVDLENRL 1680 LSKFGARCGL 1690 PQTYCVSGPN 1700 QWRDQLRPSQ 1710 LLHLFCQQHR 1720 VKAPVYRTDR 1730 VMFQDKEYSI 1740 EEIEAGRIPN 1750 PHLGPVEERL 1760 ALHVLQQQGL 1770 VPEHVESRPL 1780 YSPLQPDIEQ 1790 GKLQMWVDLF 1800 PKALGRPGPP 1810 FNITPRRARR 1820 FFLRCIIWNT 1830 RDVILDDLSL 1840 TGEKMSDIYV 1850 KGWMIGFEEH 1860 KQKTDVHYRS 1870 LGGEGNFNWR 1880 FIFPFDYLPA 1890 EQVCTIAKKD 1900 AFWRLDKTES 1910 KIPARVVFQI 1920 WDNDKFSFDD 1930 FLGSLQLDLN 1940 RMPKPAKTAK 1950 KCSLDQLDDA 1960 FHPEWFVSLF 1970 EQKTVKGWWP 1980 CVAEEGEKKI 1990 LAGKLEMTLE 2000 IVAESEHEER 2010 PAGQGRDEPN 2020 MNPKLEDPRR 2030 PDTSFLWFTS 2040 PYKTMKFILW 2050 RRFRWAIILF 2060 IILFILLLFL 2070 AIFIYAFPNY 2080 AAMKLVKPFS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0034451 centriolar satellite
Cellular Component GO:0030659 cytoplasmic vesicle membrane
Cellular Component GO:0005769 early endosome
Cellular Component GO:0030139 endocytic vesicle
Cellular Component GO:0005768 endosome
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005770 late endosome
Cellular Component GO:0031902 late endosome membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0030672 synaptic vesicle membrane
Cellular Component GO:0030315 T-tubule
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0005544 calcium-dependent phospholipid binding
Molecular Function GO:0005543 phospholipid binding
Biological Process GO:0002281 macrophage activation involved in immune response
Biological Process GO:0002280 monocyte activation involved in immune response
Biological Process GO:0050765 negative regulation of phagocytosis
Biological Process GO:0046928 regulation of neurotransmitter secretion

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.