Search Results
Overview
| Uniprot ID | O75934 |
|---|---|
| Protein Name | Pre-mRNA-splicing factor SPF27 |
| Gene Name | BCAS2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 177 | MQLTAGSKLREMESN |
Function
Required for pre-mRNA splicing as component of the activated spliceosome (PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:30705154). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR)
Protein Sequence
10
MAGTGLVAGE
20
VVVDALPYFD
30
QGYEAPGVRE
40
AAAALVEEET
50
RRYRPTKNYL
60
SYLTAPDYSA
70
FETDIMRNEF
80
ERLAARQPIE
90
LLSMKRYELP
100
APSSGQKNDI
110
TAWQECVNNS
120
MAQLEHQAVR
130
IENLELMSQH
140
GCNAWKVYNE
150
NLVHMIEHAQ
160
KELQKLRKHI
170
QDLNWQRKNM
180
QLTAGSKLRE
190
MESNWVSLVS
200
KNYEIERTIV
210
QLENEIYQIK
220
QQHGEANKEN
IRQDF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000974 | Prp19 complex |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0071007 | U2-type catalytic step 2 spliceosome |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0008380 | RNA splicing |
| Biological Process | GO:0000375 | RNA splicing, via transesterification reactions |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.