Search Results

Overview

Uniprot ID	O75937
Protein Name	DnaJ homolog subfamily C member 8
Gene Name	DNAJC8
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
108	EAVDKAYKLLLDQEQ
143	ERKKQLKKEGKPTIV
210	KREREWQKNFEESRD
231	RNFQANTKGKKEKKN
246	RTFLRPPKVKMEQRE

Function

Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells (PubMed:27133716)

Protein Sequence

10 MAASGESGTS 20 GGGGSTEEAF 30 MTFYSEVKQI 40 EKRDSVLTSK 50 NQIERLTRPG 60 SSYFNLNPFE 70 VLQIDPEVTD 80 EEIKKRFRQL 90 SILVHPDKNQ 100 DDADRAQKAF 110 EAVDKAYKLL 120 LDQEQKKRAL 130 DVIQAGKEYV 140 EHTVKERKKQ 150 LKKEGKPTIV 160 EEDDPELFKQ 170 AVYKQTMKLF 180 AELEIKRKER 190 EAKEMHERKR 200 QREEEIEAQE 210 KAKREREWQK 220 NFEESRDGRV 230 DSWRNFQANT 240 KGKKEKKNRT 250 FLRPPKVKME QRE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0030544	Hsp70 protein binding

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.