Overview
| Uniprot ID | O75943 |
|---|
| Protein Name | Cell cycle checkpoint protein RAD17 |
|---|
| Gene Name | RAD17 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 361 |
RKKGMSLKSDAVLSK |
| 368 |
KSDAVLSKSKRRKKP |
| 370 |
DAVLSKSKRRKKPDR |
Function
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Has a weak ATPase activity required for binding to chromatin (PubMed:10208430, PubMed:11418864, PubMed:11687627, PubMed:11799063, PubMed:12672690, PubMed:14624239, PubMed:15235112). Participates in the recruitment of the 9-1-1 (RAD1-RAD9-HUS1) complex and RHNO1 onto chromatin, and in CHEK1 activation (PubMed:21659603). Involved in homologous recombination by mediating recruitment of the MRN complex to DNA damage sites (PubMed:24534091). May also serve as a sensor of DNA replication progression (PubMed:12578958, PubMed:14500819, PubMed:15538388)
Protein Sequence
10
MSKTFLRPKV
20
SSTKVTDWVD
30
PSFDDFLECS
40
GVSTITATSL
50
GVNNSSHRRK
60
NGPSTLESSR
70
FPARKRGNLS
80
SLEQIYGLEN
90
SKEYLSENEP
100
WVDKYKPETQ
110
HELAVHKKKI
120
EEVETWLKAQ
130
VLERQPKQGG
140
SILLITGPPG
150
CGKTTTLKIL
160
SKEHGIQVQE
170
WINPVLPDFQ
180
KDDFKGMFNT
190
ESSFHMFPYQ
200
SQIAVFKEFL
210
LRATKYNKLQ
220
MLGDDLRTDK
230
KIILVEDLPN
240
QFYRDSHTLH
250
EVLRKYVRIG
260
RCPLIFIISD
270
SLSGDNNQRL
280
LFPKEIQEEC
290
SISNISFNPV
300
APTIMMKFLN
310
RIVTIEANKN
320
GGKITVPDKT
330
SLELLCQGCS
340
GDIRSAINSL
350
QFSSSKGENN
360
LRPRKKGMSL
370
KSDAVLSKSK
380
RRKKPDRVFE
390
NQEVQAIGGK
400
DVSLFLFRAL
410
GKILYCKRAS
420
LTELDSPRLP
430
SHLSEYERDT
440
LLVEPEEVVE
450
MSHMPGDLFN
460
LYLHQNYIDF
470
FMEIDDIVRA
480
SEFLSFADIL
490
SGDWNTRSLL
500
REYSTSIATR
510
GVMHSNKARG
520
YAHCQGGGSS
530
FRPLHKPQWF
540
LINKKYRENC
550
LAAKALFPDF
560
CLPALCLQTQ
570
LLPYLALLTI
580
PMRNQAQISF
590
IQDIGRLPLK
600
RHFGRLKMEA
610
LTDREHGMID
620
PDSGDEAQLN
630
GGHSAEESLG
640
EPTQATVPET
650
WSLPLSQNSA
660
SELPASQPQP
670
FSAQGDMEEN
680
IIIEDYESDG
T
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0140445 |
chromosome, telomeric repeat region |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0031389 |
Rad17 RFC-like complex |
| Cellular Component |
GO:0035861 |
site of double-strand break |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0140463 |
chromatin-protein adaptor activity |
| Molecular Function |
GO:0003689 |
DNA clamp loader activity |
| Biological Process |
GO:0006974 |
DNA damage response |
| Biological Process |
GO:0006281 |
DNA repair |
| Biological Process |
GO:0000076 |
DNA replication checkpoint signaling |
| Biological Process |
GO:0033314 |
mitotic DNA replication checkpoint signaling |
| Biological Process |
GO:0031573 |
mitotic intra-S DNA damage checkpoint signaling |
| Biological Process |
GO:0008156 |
negative regulation of DNA replication |
| Biological Process |
GO:1990166 |
protein localization to site of double-strand break |
| Biological Process |
GO:0042325 |
regulation of phosphorylation |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.