Search Results
Overview
| Uniprot ID | O75952 |
|---|---|
| Protein Name | Calcium-binding tyrosine phosphorylation-regulated protein |
| Gene Name | CABYR |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 364 | KKSVESVKLAQLEEN |
| 373 | AQLEENAKYSSVYME |
| 5 | ***MISSKPRLVVPY |
| 84 | QKKLECLKEPGKTSV |
Function
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium
Protein Sequence
10
MISSKPRLVV
20
PYGLKTLLEG
30
ISRAVLKTNP
40
SNINQFAAAY
50
FQELTMYRGN
60
TTMDIKDLVK
70
QFHQIKVEKW
80
SEGTTPQKKL
90
ECLKEPGKTS
100
VESKVPTQME
110
KSTDTDEDNV
120
TRTEYSDKTT
130
QFPSVYAVPG
140
TEQTEAVGGL
150
SSKPATPKTT
160
TPPSSPPPTA
170
VSPEFAYVPA
180
DPAQLAAQML
190
GKVSSIHSDQ
200
SDVLMVDVAT
210
SMPVVIKEVP
220
SSEAAEDVMV
230
AAPLVCSGKV
240
LEVQVVNQTS
250
VHVDLGSQPK
260
ENEAEPSTAS
270
SVPLQDEQEP
280
PAYDQAPEVT
290
LQADIEVMST
300
VHISSVYNDV
310
PVTEGVVYIE
320
QLPEQIVIPF
330
TDQVACLKEN
340
EQSKENEQSP
350
RVSPKSVVEK
360
TTSGMSKKSV
370
ESVKLAQLEE
380
NAKYSSVYME
390
AEATALLSDT
400
SLKGQPEVPA
410
QLLDAEGAIK
420
IGSEKSLHLE
430
VEITSIVSDN
440
TGQEESGENS
450
VPQEMEGKPV
460
LSGEAAEAVH
470
SGTSVKSSSG
480
PFPPAPEGLT
490
APEIEPEGES
TAE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0031514 | motile cilium |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0097229 | sperm end piece |
| Cellular Component | GO:0035686 | sperm fibrous sheath |
| Cellular Component | GO:0097228 | sperm principal piece |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Biological Process | GO:0003351 | epithelial cilium movement involved in extracellular fluid movement |
| Biological Process | GO:0048240 | sperm capacitation |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.