Search Results
Overview
| Uniprot ID | O75955 |
|---|---|
| Protein Name | Flotillin-1 |
| Gene Name | FLOT1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 174 | ARTAQVQKDARIGEA |
| 246 | QLQVAKTKQQIEEQR |
| 422 | SISQVNHKPLRTA** |
Function
May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles
Protein Sequence
10
MFFTCGPNEA
20
MVVSGFCRSP
30
PVMVAGGRVF
40
VLPCIQQIQR
50
ISLNTLTLNV
60
KSEKVYTRHG
70
VPISVTGIAQ
80
VKIQGQNKEM
90
LAAACQMFLG
100
KTEAEIAHIA
110
LETLEGHQRA
120
IMAHMTVEEI
130
YKDRQKFSEQ
140
VFKVASSDLV
150
NMGISVVSYT
160
LKDIHDDQDY
170
LHSLGKARTA
180
QVQKDARIGE
190
AEAKRDAGIR
200
EAKAKQEKVS
210
AQYLSEIEMA
220
KAQRDYELKK
230
AAYDIEVNTR
240
RAQADLAYQL
250
QVAKTKQQIE
260
EQRVQVQVVE
270
RAQQVAVQEQ
280
EIARREKELE
290
ARVRKPAEAE
300
RYKLERLAEA
310
EKSQLIMQAE
320
AEAASVRMRG
330
EAEAFAIGAR
340
ARAEAEQMAK
350
KAEAFQLYQE
360
AAQLDMLLEK
370
LPQVAEEISG
380
PLTSANKITL
390
VSSGSGTMGA
400
AKVTGEVLDI
410
LTRLPESVER
420
LTGVSISQVN
HKPLRTA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005912 | adherens junction |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0022409 | positive regulation of cell-cell adhesion |
| Biological Process | GO:0045807 | positive regulation of endocytosis |
| Biological Process | GO:0032226 | positive regulation of synaptic transmission, dopaminergic |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0051580 | regulation of neurotransmitter uptake |
| Biological Process | GO:0002090 | regulation of receptor internalization |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0044291 | cell-cell contact zone |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0034451 | centriolar satellite |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0098691 | dopaminergic synapse |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016600 | flotillin complex |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0005815 | microtubule organizing center |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0048786 | presynaptic active zone |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0001931 | uropod |
| Molecular Function | GO:0035255 | ionotropic glutamate receptor binding |
| Molecular Function | GO:0002020 | protease binding |
| Biological Process | GO:0034332 | adherens junction organization |
| Biological Process | GO:0070836 | caveola assembly |
| Biological Process | GO:0044331 | cell-cell adhesion mediated by cadherin |
| Biological Process | GO:0007043 | cell-cell junction assembly |
| Biological Process | GO:0022617 | extracellular matrix disassembly |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0044854 | plasma membrane raft assembly |
| Biological Process | GO:0044857 | plasma membrane raft organization |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.