Search Results

Overview

Uniprot IDO75962
Protein NameTriple functional domain protein
Gene NameTRIO
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1775 RPGNTLRKWLTSPVR

Function

Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:22155786, PubMed:27418539, PubMed:8643598). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity)

Protein Sequence

10 MSGSSGGAAA 20 PAASSGPAAA 30 ASAAGSGCGG 40 GAGEGAEEAA 50 KDLADIAAFF 60 RSGFRKNDEM 70 KAMDVLPILK 80 EKVAYLSGGR 90 DKRGGPILTF 100 PARSNHDRIR 110 QEDLRRLISY 120 LACIPSEEVC 130 KRGFTVIVDM 140 RGSKWDSIKP 150 LLKILQESFP 160 CCIHVALIIK 170 PDNFWQKQRT 180 NFGSSKFEFE 190 TNMVSLEGLT 200 KVVDPSQLTP 210 EFDGCLEYNH 220 EEWIEIRVAF 230 EDYISNATHM 240 LSRLEELQDI 250 LAKKELPQDL 260 EGARNMIEEH 270 SQLKKKVIKA 280 PIEDLDLEGQ 290 KLLQRIQSSE 300 SFPKKNSGSG 310 NADLQNLLPK 320 VSTMLDRLHS 330 TRQHLHQMWH 340 VRKLKLDQCF 350 QLRLFEQDAE 360 KMFDWITHNK 370 GLFLNSYTEI 380 GTSHPHAMEL 390 QTQHNHFAMN 400 CMNVYVNINR 410 IMSVANRLVE 420 SGHYASQQIR 430 QIASQLEQEW 440 KAFAAALDER 450 STLLDMSSIF 460 HQKAEKYMSN 470 VDSWCKACGE 480 VDLPSELQDL 490 EDAIHHHQGI 500 YEHITLAYSE 510 VSQDGKSLLD 520 KLQRPLTPGS 530 SDSLTASANY 540 SKAVHHVLDV 550 IHEVLHHQRQ 560 LENIWQHRKV 570 RLHQRLQLCV 580 FQQDVQQVLD 590 WIENHGEAFL 600 SKHTGVGKSL 610 HRARALQKRH 620 EDFEEVAQNT 630 YTNADKLLEA 640 AEQLAQTGEC 650 DPEEIYQAAH 660 QLEDRIQDFV 670 RRVEQRKILL 680 DMSVSFHTHV 690 KELWTWLEEL 700 QKELLDDVYA 710 ESVEAVQDLI 720 KRFGQQQQTT 730 LQVTVNVIKE 740 GEDLIQQLRD 750 SAISSNKTPH 760 NSSINHIETV 770 LQQLDEAQSQ 780 MEELFQERKI 790 KLELFLQLRI 800 FERDAIDIIS 810 DLESWNDELS 820 QQMNDFDTED 830 LTIAEQRLQH 840 HADKALTMNN 850 LTFDVIHQGQ 860 DLLQYVNEVQ 870 ASGVELLCDR 880 DVDMATRVQD 890 LLEFLHEKQQ 900 ELDLAAEQHR 910 KHLEQCVQLR 920 HLQAEVKQVL 930 GWIRNGESML 940 NAGLITASSL 950 QEAEQLQREH 960 EQFQHAIEKT 970 HQSALQVQQK 980 AEAMLQANHY 990 DMDMIRDCAE 1000 KVASHWQQLM 1010 LKMEDRLKLV 1020 NASVAFYKTS 1030 EQVCSVLESL 1040 EQEYKREEDW 1050 CGGADKLGPN 1060 SETDHVTPMI 1070 SKHLEQKEAF 1080 LKACTLARRN 1090 ADVFLKYLHR 1100 NSVNMPGMVT 1110 HIKAPEQQVK 1120 NILNELFQRE 1130 NRVLHYWTMR 1140 KRRLDQCQQY 1150 VVFERSAKQA 1160 LEWIHDNGEF 1170 YLSTHTSTGS 1180 SIQHTQELLK 1190 EHEEFQITAK 1200 QTKERVKLLI 1210 QLADGFCEKG 1220 HAHAAEIKKC 1230 VTAVDKRYRD 1240 FSLRMEKYRT 1250 SLEKALGISS 1260 DSNKSSKSLQ 1270 LDIIPASIPG 1280 SEVKLRDAAH 1290 ELNEEKRKSA 1300 RRKEFIMAEL 1310 IQTEKAYVRD 1320 LRECMDTYLW 1330 EMTSGVEEIP 1340 PGIVNKELII 1350 FGNMQEIYEF 1360 HNNIFLKELE 1370 KYEQLPEDVG 1380 HCFVTWADKF 1390 QMYVTYCKNK 1400 PDSTQLILEH 1410 AGSYFDEIQQ 1420 RHGLANSISS 1430 YLIKPVQRIT 1440 KYQLLLKELL 1450 TCCEEGKGEI 1460 KDGLEVMLSV 1470 PKRANDAMHL 1480 SMLEGFDENI 1490 ESQGELILQE 1500 SFQVWDPKTL 1510 IRKGRERHLF 1520 LFEMSLVFSK 1530 EVKDSSGRSK 1540 YLYKSKLFTS 1550 ELGVTEHVEG 1560 DPCKFALWVG 1570 RTPTSDNKIV 1580 LKASSIENKQ 1590 DWIKHIREVI 1600 QERTIHLKGA 1610 LKEPIHIPKT 1620 APATRQKGRR 1630 DGEDLDSQGD 1640 GSSQPDTISI 1650 ASRTSQNTLD 1660 SDKLSGGCEL 1670 TVVIHDFTAC 1680 NSNELTIRRG 1690 QTVEVLERPH 1700 DKPDWCLVRT 1710 TDRSPAAEGL 1720 VPCGSLCIAH 1730 SRSSMEMEGI 1740 FNHKDSLSVS 1750 SNDASPPASV 1760 ASLQPHMIGA 1770 QSSPGPKRPG 1780 NTLRKWLTSP 1790 VRRLSSGKAD 1800 GHVKKLAHKH 1810 KKSREVRKSA 1820 DAGSQKDSDD 1830 SAATPQDETV 1840 EERGRNEGLS 1850 SGTLSKSSSS 1860 GMQSCGEEEG 1870 EEGADAVPLP 1880 PPMAIQQHSL 1890 LQPDSQDDKA 1900 SSRLLVRPTS 1910 SETPSAAELV 1920 SAIEELVKSK 1930 MALEDRPSSL 1940 LVDQGDSSSP 1950 SFNPSDNSLL 1960 SSSSPIDEME 1970 ERKSSSLKRR 1980 HYVLQELVET 1990 ERDYVRDLGY 2000 VVEGYMALMK 2010 EDGVPDDMKG 2020 KDKIVFGNIH 2030 QIYDWHRDFF 2040 LGELEKCLED 2050 PEKLGSLFVK 2060 HERRLHMYIA 2070 YCQNKPKSEH 2080 IVSEYIDTFF 2090 EDLKQRLGHR 2100 LQLTDLLIKP 2110 VQRIMKYQLL 2120 LKDFLKYSKK 2130 ASLDTSELER 2140 AVEVMCIVPR 2150 RCNDMMNVGR 2160 LQGFDGKIVA 2170 QGKLLLQDTF 2180 LVTDQDAGLL 2190 PRCRERRIFL 2200 FEQIVIFSEP 2210 LDKKKGFSMP 2220 GFLFKNSIKV 2230 SCLCLEENVE 2240 NDPCKFALTS 2250 RTGDVVETFI 2260 LHSSSPSVRQ 2270 TWIHEINQIL 2280 ENQRNFLNAL 2290 TSPIEYQRNH 2300 SGGGGGGGSG 2310 GSGGGGGSGG 2320 GGAPSGGSGH 2330 SGGPSSCGGA 2340 PSTSRSRPSR 2350 IPQPVRHHPP 2360 VLVSSAASSQ 2370 AEADKMSGTS 2380 TPGPSLPPPG 2390 AAPEAGPSAP 2400 SRRPPGADAE 2410 GSEREAEPIP 2420 KMKVLESPRK 2430 GAANASGSSP 2440 DAPAKDARAS 2450 LGTLPLGKPR 2460 AGAASPLNSP 2470 LSSAVPSLGK 2480 EPFPPSSPLQ 2490 KGGSFWSSIP 2500 ASPASRPGSF 2510 TFPGDSDSLQ 2520 RQTPRHAAPG 2530 KDTDRMSTCS 2540 SASEQSVQST 2550 QSNGSESSSS 2560 SNISTMLVTH 2570 DYTAVKEDEI 2580 NVYQGEVVQI 2590 LASNQQNMFL 2600 VFRAATDQCP 2610 AAEGWIPGFV 2620 LGHTSAVIVE 2630 NPDGTLKKST 2640 SWHTALRLRK 2650 KSEKKDKDGK 2660 REGKLENGYR 2670 KSREGLSNKV 2680 SVKLLNPNYI 2690 YDVPPEFVIP 2700 LSEVTCETGE 2710 TVVLRCRVCG 2720 RPKASITWKG 2730 PEHNTLNNDG 2740 HYSISYSDLG 2750 EATLKIVGVT 2760 TEDDGIYTCI 2770 AVNDMGSASS 2780 SASLRVLGPG 2790 MDGIMVTWKD 2800 NFDSFYSEVA 2810 ELGRGRFSVV 2820 KKCDQKGTKR 2830 AVATKFVNKK 2840 LMKRDQVTHE 2850 LGILQSLQHP 2860 LLVGLLDTFE 2870 TPTSYILVLE 2880 MADQGRLLDC 2890 VVRWGSLTEG 2900 KIRAHLGEVL 2910 EAVRYLHNCR 2920 IAHLDLKPEN 2930 ILVDESLAKP 2940 TIKLADFGDA 2950 VQLNTTYYIH 2960 QLLGNPEFAA 2970 PEIILGNPVS 2980 LTSDTWSVGV 2990 LTYVLLSGVS 3000 PFLDDSVEET 3010 CLNICRLDFS 3020 FPDDYFKGVS 3030 QKAKEFVCFL 3040 LQEDPAKRPS 3050 AALALQEQWL 3060 QAGNGRSTGV 3070 LDTSRLTSFI 3080 ERRKHQNDVR 3090 PIRSIKNFLQ SRLLPRV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0042995 cell projection
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0019898 extrinsic component of membrane
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0048786 presynaptic active zone
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0106310 protein serine kinase activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
Biological Process GO:0007411 axon guidance
Biological Process GO:0007185 cell surface receptor protein tyrosine phosphatase signaling pathway
Biological Process GO:0045599 negative regulation of fat cell differentiation
Biological Process GO:0048812 neuron projection morphogenesis
Biological Process GO:0099170 postsynaptic modulation of chemical synaptic transmission
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.