Search Results
Overview
| Uniprot ID | O75969 |
|---|---|
| Protein Name | A-kinase anchor protein 3 |
| Gene Name | AKAP3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | LHFEMTHKEIPCQGP |
| 173 | TPTKSLSKIASELVN |
| 194 | SRNAAPDKAPGSGDR |
| 237 | PDDKPPSKKSFFYKE |
| 238 | DDKPPSKKSFFYKEV |
| 243 | SKKSFFYKEVFESRN |
| 305 | VSIMKTLKIQVKDTT |
| 31 | DNQAQDWKMDTSTDP |
| 369 | VFSHGSQKATDIMDA |
| 389 | YNVMFAKKVPEHVRK |
| 396 | KVPEHVRKAQDKAES |
| 400 | HVRKAQDKAESYSLI |
| 410 | SYSLISMKGMGDPKN |
| 416 | MKGMGDPKNRNVNFA |
| 425 | RNVNFAMKSETKLRE |
| 433 | SETKLREKMYSEPKS |
| 439 | EKMYSEPKSEEETCA |
| 447 | SEEETCAKTLGEHII |
| 455 | TLGEHIIKEGLTLWH |
| 470 | KTQQKECKSLGFQHA |
| 51 | WLRRDLEKSTAEFQD |
| 608 | LLSETIFKRDQSPEP |
| 616 | RDQSPEPKVPEQPVK |
| 623 | KVPEQPVKEDRKLCE |
| 627 | QPVKEDRKLCERPLA |
| 699 | LAELGDDKSGDASRL |
| 79 | SNSGDPHKGFSVDYY |
| 91 | DYYNTTTKGTPERLH |
Function
Structural component of sperm fibrous sheath (By similarity). Required for the formation of the subcellular structure of the sperm flagellum, sperm motility and male fertility (PubMed:35228300)
Protein Sequence
10
MSEKVDWLQS
20
QNGVCKVDVY
30
SPGDNQAQDW
40
KMDTSTDPVR
50
VLSWLRRDLE
60
KSTAEFQDVR
70
FKPGESFGGE
80
TSNSGDPHKG
90
FSVDYYNTTT
100
KGTPERLHFE
110
MTHKEIPCQG
120
PRAQLGNGSS
130
VDEVSFYANR
140
LTNLVIAMAR
150
KEINEKIDGS
160
ENKCVYQSLY
170
MGNEPTPTKS
180
LSKIASELVN
190
ETVSACSRNA
200
APDKAPGSGD
210
RVSGSSQSPP
220
NLKYKSTLKI
230
KESTKERQGP
240
DDKPPSKKSF
250
FYKEVFESRN
260
GDYAREGGRF
270
FPRERKRFRG
280
QERPDDFTAS
290
VSEGIMTYAN
300
SVVSDMMVSI
310
MKTLKIQVKD
320
TTIATILLKK
330
VLLKHAKEVV
340
SDLIDSFLRN
350
LHSVTGTLMT
360
DTQFVSAVKR
370
TVFSHGSQKA
380
TDIMDAMLRK
390
LYNVMFAKKV
400
PEHVRKAQDK
410
AESYSLISMK
420
GMGDPKNRNV
430
NFAMKSETKL
440
REKMYSEPKS
450
EEETCAKTLG
460
EHIIKEGLTL
470
WHKTQQKECK
480
SLGFQHAAFE
490
APNTQRKPAS
500
DISFEYPEDI
510
GNLSLPPYPP
520
EKPENFMYDS
530
DSWAEDLIVS
540
ALLLIQYHLA
550
QGGRRDARSF
560
VEAAGTTNFP
570
ANEPPVAPDE
580
SCLKSAPIVG
590
DQEQAEKKDL
600
RSVFFNFIRN
610
LLSETIFKRD
620
QSPEPKVPEQ
630
PVKEDRKLCE
640
RPLASSPPRL
650
YEDDETPGAL
660
SGLTKMAVSQ
670
IDGHMSGQMV
680
EHLMNSVMKL
690
CVIIAKSCDA
700
SLAELGDDKS
710
GDASRLTSAF
720
PDSLYECLPA
730
KGTGSAEAVL
740
QNAYQAIHNE
750
MRGTSGQPPE
760
GCAAPTVIVS
770
NHNLTDTVQN
780
KQLQAVLQWV
790
AASELNVPIL
800
YFAGDDEGIQ
810
EKLLQLSAAA
820
VDKGCSVGEV
830
LQSVLRYEKE
840
RQLNEAVGNV
850
TPLQLLDWLM
VNL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0035686 | sperm fibrous sheath |
| Cellular Component | GO:0097225 | sperm midpiece |
| Cellular Component | GO:0097228 | sperm principal piece |
| Molecular Function | GO:0051018 | protein kinase A binding |
| Biological Process | GO:0007340 | acrosome reaction |
| Biological Process | GO:0007178 | cell surface receptor protein serine/threonine kinase signaling pathway |
| Biological Process | GO:0045184 | establishment of protein localization |
| Biological Process | GO:0030317 | flagellated sperm motility |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0007338 | single fertilization |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.