Search Results
Overview
| Uniprot ID | O76003 |
|---|---|
| Protein Name | Glutaredoxin-3 |
| Gene Name | GLRX3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 151 | APCMLFMKGTPQEPR |
| 217 | IGGLDIIKELEASEE |
Function
Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thioredoxin activity since it lacks the conserved motif that is essential for catalytic activity
Protein Sequence
10
MAAGAAEAAV
20
AAVEEVGSAG
30
QFEELLRLKA
40
KSLLVVHFWA
50
PWAPQCAQMN
60
EVMAELAKEL
70
PQVSFVKLEA
80
EGVPEVSEKY
90
EISSVPTFLF
100
FKNSQKIDRL
110
DGAHAPELTK
120
KVQRHASSGS
130
FLPSANEHLK
140
EDLNLRLKKL
150
THAAPCMLFM
160
KGTPQEPRCG
170
FSKQMVEILH
180
KHNIQFSSFD
190
IFSDEEVRQG
200
LKAYSSWPTY
210
PQLYVSGELI
220
GGLDIIKELE
230
ASEELDTICP
240
KAPKLEERLK
250
VLTNKASVML
260
FMKGNKQEAK
270
CGFSKQILEI
280
LNSTGVEYET
290
FDILEDEEVR
300
QGLKAYSNWP
310
TYPQLYVKGE
320
LVGGLDIVKE
330
LKENGELLPI
LRGEN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0051536 | iron-sulfur cluster binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0005080 | protein kinase C binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0044571 | [2Fe-2S] cluster assembly |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0006879 | intracellular iron ion homeostasis |
| Biological Process | GO:0016226 | iron-sulfur cluster assembly |
| Biological Process | GO:0010614 | negative regulation of cardiac muscle hypertrophy |
| Biological Process | GO:0002026 | regulation of the force of heart contraction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.