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Overview

Uniprot IDO76041
Protein NameNebulette
Gene NameNEBL
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
811 PVTERVRKNTQVVSD

Function

Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres (PubMed:27733623)

Protein Sequence

10 MRVPVFEDIK 20 DETEEEKIGE 30 EENEEDQVFY 40 KPVIEDLSME 50 LARKCTELIS 60 DIRYKEEFKK 70 SKDKCTFVTD 80 SPMLNHVKNI 90 GAFISEAKYK 100 GTIKADLSNS 110 LYKRMPATID 120 SVFAGEVTQL 130 QSEVAYKQKH 140 DAAKGFSDYA 150 HMKEPPEVKH 160 AMEVNKHQSN 170 ISYRKDVQDT 180 HTYSAELDRP 190 DIKMATQISK 200 IISNAEYKKG 210 QGIMNKEPAV 220 IGRPDFEHAV 230 EASKLSSQIK 240 YKEKFDNEMK 250 DKKHHYNPLE 260 SASFRQNQLA 270 ATLASNVKYK 280 KDIQNMHDPV 290 SDLPNLLFLD 300 HVLKASKMLS 310 GREYKKLFEE 320 NKGMYHFDAD 330 AVEHLHHKGN 340 AVLQSQVKYK 350 EEYEKNKGKP 360 MLEFVETPSY 370 QASKEAQKMQ 380 SEKVYKEDFE 390 KEIKGRSSLD 400 LDKTPEFLHV 410 KYITNLLREK 420 EYKKDLENEI 430 KGKGMELNSE 440 VLDIQRAKRA 450 SEMASEKEYK 460 KDLESIIKGK 470 GMQAGTDTLE 480 MQHAKKAAEI 490 ASEKDYKRDL 500 ETEIKGKGMQ 510 VSTDTLDVQR 520 AKKASEMASQ 530 KQYKKDLENE 540 IKGKGMQVSM 550 DIPDILRAKR 560 TSEIYSQRKY 570 KDEAEKMLSN 580 YSTIADTPEI 590 QRIKTTQQNI 600 SAVFYKKEVG 610 AGTAVKDSPE 620 IERVKKNQQN 630 ISSVKYKEEI 640 KHATAISDPP 650 ELKRVKENQK 660 NISNLQYKEQ 670 NYKATPVSMT 680 PEIERVRRNQ 690 EQLSAVKYKG 700 ELQRGTAISD 710 PPELKRAKEN 720 QKNISNVYYR 730 GQLGRATTLS 740 VTPEMERVKK 750 NQENISSVKY 760 TQDHKQMKGR 770 PSLILDTPAM 780 RHVKEAQNHI 790 SMVKYHEDFE 800 KTKGRGFTPV 810 VDDPVTERVR 820 KNTQVVSDAA 830 YKGVHPHIVE 840 MDRRPGIIVD 850 LKVWRTDPGS 860 IFDLDPLEDN 870 IQSRSLHMLS 880 EKASHYRRHW 890 SRSHSSSTFG 900 TGLGDDRSEI 910 SEIYPSFSCC 920 SEVTRPSDEG 930 APVLPGAYQQ 940 SHSQGYGYMH 950 QTSVSSMRSM 960 QHSPNLRTYR 970 AMYDYSAQDE 980 DEVSFRDGDY 990 IVNVQPIDDG 1000 WMYGTVQRTG 1010 RTGMLPANYI EFVN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031674 I band
Cellular Component GO:0001725 stress fiber
Cellular Component GO:0030018 Z disc
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0008092 cytoskeletal protein binding
Molecular Function GO:0031005 filamin binding
Molecular Function GO:0008307 structural constituent of muscle
Molecular Function GO:0005523 tropomyosin binding
Biological Process GO:0071691 cardiac muscle thin filament assembly

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.