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Overview

Uniprot IDO76054
Protein NameSEC14-like protein 2
Gene NameSEC14L2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
117 GLLFSASKQDLLRTK
193 LKRLFVVKAPKLFPV
257 GNPKCKSKINYGGDI
275 YYVRDQVKQQYEHSV
375 TYSFIHAKKVNFTVE
393 PDKASEEKMKQLGAG
51 ARSFDLQKSEAMLRK

Function

Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell

Protein Sequence

10 MSGRVGDLSP 20 RQKEALAKFR 30 ENVQDVLPAL 40 PNPDDYFLLR 50 WLRARSFDLQ 60 KSEAMLRKHV 70 EFRKQKDIDN 80 IISWQPPEVI 90 QQYLSGGMCG 100 YDLDGCPVWY 110 DIIGPLDAKG 120 LLFSASKQDL 130 LRTKMRECEL 140 LLQECAHQTT 150 KLGRKVETIT 160 IIYDCEGLGL 170 KHLWKPAVEA 180 YGEFLCMFEE 190 NYPETLKRLF 200 VVKAPKLFPV 210 AYNLIKPFLS 220 EDTRKKIMVL 230 GANWKEVLLK 240 HISPDQVPVE 250 YGGTMTDPDG 260 NPKCKSKINY 270 GGDIPRKYYV 280 RDQVKQQYEH 290 SVQISRGSSH 300 QVEYEILFPG 310 CVLRWQFMSD 320 GADVGFGIFL 330 KTKMGERQRA 340 GEMTEVLPNQ 350 RYNSHLVPED 360 GTLTCSDPGI 370 YVLRFDNTYS 380 FIHAKKVNFT 390 VEVLLPDKAS 400 EEKMKQLGAG TPK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005543 phospholipid binding
Molecular Function GO:0008431 vitamin E binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0045540 regulation of cholesterol biosynthetic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.