Search Results
Overview
| Uniprot ID | O76062 |
|---|---|
| Protein Name | Delta(14)-sterol reductase TM7SF2 |
| Gene Name | TM7SF2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 311 | FRGANSQKNTFRKNP |
| 83 | LYLLPARKVAEGQEL |
Function
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis
Protein Sequence
10
MAPTQGPRAP
20
LEFGGPLGAA
30
ALLLLLPATM
40
FHLLLAARSG
50
PARLLGPPAS
60
LPGLEVLWSP
70
RALLLWLAWL
80
GLQAALYLLP
90
ARKVAEGQEL
100
KDKSRLRYPI
110
NGFQALVLTA
120
LLVGLGMSAG
130
LPLGALPEML
140
LPLAFVATLT
150
AFIFSLFLYM
160
KAQVAPVSAL
170
APGGNSGNPI
180
YDFFLGRELN
190
PRICFFDFKY
200
FCELRPGLIG
210
WVLINLALLM
220
KEAELRGSPS
230
LAMWLVNGFQ
240
LLYVGDALWH
250
EEAVLTTMDI
260
THDGFGFMLA
270
FGDMAWVPFT
280
YSLQAQFLLH
290
HPQPLGLPMA
300
SVICLINATG
310
YYIFRGANSQ
320
KNTFRKNPSD
330
PRVAGLETIS
340
TATGRKLLVS
350
GWWGMVRHPN
360
YLGDLIMALA
370
WSLPCGVSHL
380
LPYFYLLYFT
390
ALLVHREARD
400
ERQCLQKYGL
410
AWQEYCRRVP
YRIMPYIY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005637 | nuclear inner membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0043235 | receptor complex |
| Molecular Function | GO:0050613 | Delta14-sterol reductase activity |
| Molecular Function | GO:0050661 | NADP binding |
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
| Biological Process | GO:0033490 | cholesterol biosynthetic process via lathosterol |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.