Search Results
Overview
| Uniprot ID | O76070 |
|---|---|
| Protein Name | Gamma-synuclein |
| Gene Name | SNCG |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 12 | KKGFSIAKEGVVGAV |
| 21 | GVVGAVEKTKQGVTE |
| 23 | VGAVEKTKQGVTEAA |
| 32 | GVTEAAEKTKEGVMY |
| 34 | TEAAEKTKEGVMYVG |
| 45 | MYVGAKTKENVVQSV |
| 58 | SVTSVAEKTKEQANA |
| 6 | **MDVFKKGFSIAKE |
| 60 | TSVAEKTKEQANAVS |
| 97 | VTSGVVRKEDLRPSA |
Function
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043679 | axon terminus |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005819 | spindle |
| Molecular Function | GO:1903136 | cuprous ion binding |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0009306 | protein secretion |
| Biological Process | GO:0050808 | synapse organization |
| Biological Process | GO:0048488 | synaptic vesicle endocytosis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.