Overview
| Uniprot ID | O77591 |
|---|
| Protein Name | Inositol monophosphatase 1 |
|---|
| Gene Name | IMPA1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 145 |
GAFCDGQKLQVSPQK |
Function
Phosphatase involved in the dephosphorylation of myo-inositol monophosphate to generate myo-inositol. Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate. Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP. Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides, and involved in maintaining normal brain function. Has been implicated as the pharmacological target for lithium Li(+) action in brain
Protein Sequence
10
MADPWQECMD
20
YAVTLARQAG
30
EIVREALKNE
40
MNIMIKSSPA
50
DLVTATDEKV
60
EKMLISSIKE
70
KYPSHSFIGE
80
ESVAAGEKSV
90
LTDNPTWIID
100
PIDGTTNFVH
110
GFPFVAVSIG
120
FVVNKGMEFG
130
VVYSCMEDKM
140
YTGRKGRGAF
150
CDGQKLQVSP
160
QKDVTNSLLV
170
TELGSSRTPE
180
TVRIILSNME
190
RLLCIPIHGI
200
RGVGTAALNM
210
CFVAAGVADA
220
FYEMGIHCWD
230
MAGAGIIVTE
240
AGGVLMDITG
250
GPFDLMSRRV
260
IASSNKALGE
270
RIAKEIQIIP
LQRDDED
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Molecular Function |
GO:0103026 |
fructose-1-phosphatase activity |
| Molecular Function |
GO:0008877 |
glucose-1-phosphatase activity |
| Molecular Function |
GO:0004346 |
glucose-6-phosphatase activity |
| Molecular Function |
GO:0047954 |
glycerol-2-phosphatase activity |
| Molecular Function |
GO:0008934 |
inositol monophosphate 1-phosphatase activity |
| Molecular Function |
GO:0052832 |
inositol monophosphate 3-phosphatase activity |
| Molecular Function |
GO:0052833 |
inositol monophosphate 4-phosphatase activity |
| Molecular Function |
GO:0052834 |
inositol monophosphate phosphatase activity |
| Molecular Function |
GO:0031403 |
lithium ion binding |
| Molecular Function |
GO:0000287 |
magnesium ion binding |
| Molecular Function |
GO:0030145 |
manganese ion binding |
| Biological Process |
GO:0006021 |
inositol biosynthetic process |
| Biological Process |
GO:0006020 |
inositol metabolic process |
| Biological Process |
GO:0046854 |
phosphatidylinositol phosphate biosynthetic process |
| Biological Process |
GO:0007165 |
signal transduction |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.