Search Results

Overview

Uniprot IDO77636
Protein NameDisintegrin and metalloproteinase domain-containing protein 17
Gene NameADAM17
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
523 DRNSPCCKNCQFETA

Function

Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity (By similarity). Cleaves the membrane-bound precursor of TNF to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2 (By similarity). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R. Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (By similarity)

Protein Sequence

10 MRQCALFLTS 20 LVPIVLAPRP 30 PDEPGFGSPQ 40 RLEKLDSLLS 50 DYDILSLSSI 60 RQHSVRKRDL 70 QASTHLETLL 80 TFSALNRHFK 90 LYLTSSTERF 100 SQNFKVVVVD 110 GEDESEYPVK 120 WQDFFSGHVV 130 GEPDSRVLAH 140 IGDDDITVRI 150 NTDGAEYNIE 160 PLWRLINDTK 170 DKRVLVYKSE 180 DIKNVSRLQS 190 PKVCGYIKAD 200 NEELLPKGLV 210 DREPPDELVH 220 RVKRRADPNP 230 LRNTCKLLVV 240 ADHRFYKYMG 250 RGEESTTTNY 260 LIELIDRVDD 270 IYRNTSWDNA 280 GFKGYGIQIE 290 QIRILKSPQE 300 VKPGERHYNM 310 AKSYPNEEKD 320 AWDVKMLLEQ 330 FSFDIAEEAS 340 KVCLAHLFTY 350 QDFDMGTLGL 360 AYVGSPRANS 370 HGGVCPKAYY 380 SPIGKKNIYL 390 NSGLTSTKNY 400 GKTILTKEAD 410 LVTTHELGHN 420 FGAEHDPDGL 430 AECAPNEDQG 440 GKYVMYPIAV 450 SGDHENNKMF 460 SNCSKQSIYK 470 TIESKAQECF 480 QERSNKVCGN 490 SRVDEGEECD 500 PGIMYLNNDT 510 CCNSDCTLRP 520 GVQCSDRNSP 530 CCKNCQFETA 540 QKKCQEAINA 550 TCKGVSYCTG 560 NSSECPPPGN 570 AEDDTVCLDL 580 GRCKDGKCVP 590 FCEREQRLES 600 CACNETDHSC 610 KVCCRAPSGR 620 CLPYVDAEQK 630 NLFLRKGKPC 640 TVGFCDMNGK 650 CEKRVQDVIE 660 RFWEFIDKLS 670 INTFGKFLAD 680 NIVGSVLVFS 690 LMLWIPVSIL 700 VHCVDKKLDK 710 QYESLSLLHP 720 SNVEMLSSMD 730 SASVRIIKPF 740 PAPQTPGRLQ 750 PLQPLQPGPV 760 LPSAPSVPVA 770 PKLDHQRMDT 780 IQEDPSTDSH 790 VDEDGFEKDP 800 FPNSSAAAKS 810 FEDLTDHPVT 820 RSEKASSFKL 830 QRQSRVDSKE TEC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0004175 endopeptidase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0004222 metalloendopeptidase activity
Molecular Function GO:0005112 Notch binding
Biological Process GO:0006509 membrane protein ectodomain proteolysis
Biological Process GO:0007220 Notch receptor processing
Biological Process GO:0007219 Notch signaling pathway
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0006508 proteolysis
Biological Process GO:0033209 tumor necrosis factor-mediated signaling pathway

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.