Search Results
Overview
| Uniprot ID | O88346 |
|---|---|
| Protein Name | Troponin T, slow skeletal muscle |
| Gene Name | Tnnt1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | EEELIALKDRIERRR |
| 90 | DVHFEQRKKEEEELI |
| 91 | VHFEQRKKEEEELIA |
Function
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity
Protein Sequence
10
MSDTEEQEYE
20
EEQAEDEEAV
30
EEEEAPEEPE
40
PVAEREEERP
50
KPSRPVVPPL
60
IPPKIPEGER
70
VDFDDIHRKR
80
MEKDLLELQT
90
LIDVHFEQRK
100
KEEEELIALK
110
DRIERRRAER
120
AEQQRFRTEK
130
ERERQAKLAE
140
EKMRKEEEEA
150
KKRAEDDAKK
160
KKVLSNMGAH
170
FGGYLVKAEQ
180
KRGKRQTGRE
190
MKLRILSERK
200
KPLNIDYMGE
210
DQLREKAQEL
220
SEWIHQLESE
230
KFDLMEKLKQ
240
QKYEINVLYN
250
RISHAQKFRK
260
GAGKGRVGGR
WK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005861 | troponin complex |
| Molecular Function | GO:0005523 | tropomyosin binding |
| Molecular Function | GO:0031014 | troponin T binding |
| Biological Process | GO:0045932 | negative regulation of muscle contraction |
| Biological Process | GO:0045214 | sarcomere organization |
| Biological Process | GO:0003009 | skeletal muscle contraction |
| Biological Process | GO:0031444 | slow-twitch skeletal muscle fiber contraction |
| Biological Process | GO:0014883 | transition between fast and slow fiber |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.