Search Results
Overview
| Uniprot ID | O88407 |
|---|---|
| Protein Name | Protein lifeguard 2 |
| Gene Name | Faim2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 5 | ***MTQGKLSVANKA |
Function
Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development (By similarity)
Protein Sequence
10
MTQGKLSVAN
20
KAPGTEGQQQ
30
ANGEKKDAPA
40
VPSAPPSYEE
50
ATSGEGLKAG
60
AFPQGPTAVP
70
LHPSWAYVDP
80
SSSSGYEGGF
90
PAGHHELFST
100
FSWDDQKVRQ
110
LFIRKVYTIL
120
LVQLLVTLAV
130
VALFTFCDVV
140
KDYVQANPGW
150
YWASYAVFFA
160
TYLTLACCSG
170
PRRHFPWNLI
180
LLTIFTLSMA
190
YLTGMLSSYY
200
NTTSVLLCLG
210
ITALVCLSVT
220
IFSFQTKFDF
230
TSCHGVLFVL
240
LMTLFFSGLL
250
LAILLPFQYV
260
PWLHAVYAVL
270
GAGVFTLFLA
280
FDTQLLMGNR
290
RHSLSPEEYI
300
FGALNIYLDI
310
IYIFTFFLQL
FGTNRE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Molecular Function | GO:0005262 | calcium channel activity |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0021681 | cerebellar granular layer development |
| Biological Process | GO:0021702 | cerebellar Purkinje cell differentiation |
| Biological Process | GO:0021680 | cerebellar Purkinje cell layer development |
| Biological Process | GO:0021549 | cerebellum development |
| Biological Process | GO:2001234 | negative regulation of apoptotic signaling pathway |
| Biological Process | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| Biological Process | GO:0043524 | negative regulation of neuron apoptotic process |
| Biological Process | GO:0043523 | regulation of neuron apoptotic process |
| Biological Process | GO:0002931 | response to ischemia |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.