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Overview

Uniprot IDO88453
Protein NameScaffold attachment factor B1
Gene NameSafb
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
378 DSKDDVKKFAFDACN
592 TVVMDKSKGVPVISV

Function

Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (By similarity). Thereby acts as a negative regulator of cell proliferation (By similarity). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity)

Protein Sequence

10 MAETLSGLGD 20 SGAASAAAVS 30 SAASETGTRR 40 LSDLRVIDLR 50 AELRKRNLTS 60 SGNKSVLMER 70 LKKAIEEEGG 80 NPDEIEVISE 90 GNKKMPKRPS 100 KGKKPEDEGV 110 EDNGLEENSG 120 DGQEDVETSL 130 ENLQDMDMMD 140 ISVLDEADID 150 NGSVADCVEE 160 EEEATLPEGL 170 GLLRIGRLQS 180 KGLPEQLQEL 190 AIDDKEAINN 200 VDTSSSDFTI 210 LQEMEEASLE 220 PENEKILDIL 230 GETCKSEPVK 240 EEGSELEQPF 250 AQATSSVGPD 260 RKLAEEEDLF 270 ESCGHPEEEE 280 EEEEEEEQEE 290 EQEEEGDLAL 300 ASSSKSESSS 310 TRCQWSEADA 320 LLAVVKREPA 330 EAPGGGTGMD 340 REPVGLEEPV 350 EQSSTAAQLP 360 ETTSQELVRA 370 PTAAPSPEPR 380 DSKDDVKKFA 390 FDACNDVPAA 400 PKESSASEGA 410 DQKMSSVEDD 420 SDTKRLSREE 430 KGRSSCGRNF 440 WVSGLSSTTR 450 ATDLKNLFSR 460 YGKVVGAKVV 470 TNARSPGARC 480 YGFVTMSTAE 490 EATKCINHLH 500 KTELHGKMIS 510 VEKAKSEPAG 520 KRVPDRRDGD 530 SKKEKTSTSD 540 RSANLKREEK 550 GDRKDDAKKT 560 DDGSTEKSKD 570 ADDQKPGPSE 580 RSRTTKSGSR 590 GTERTVVMDK 600 SKGVPVISVK 610 TSGSKERASK 620 SQDRKSVSRE 630 KRSVVSFDKV 640 KESRKSRDSE 650 SRRERERERS 660 EREQRLQAQW 670 EREERERLEI 680 ARERLAFHRH 690 RLERERMERE 700 RLERERMHVE 710 QERRREQERI 720 HREREELRRQ 730 QELRYEQERR 740 PAVRRPYEVD 750 GRRDDAYWPE 760 AKRAALDDRY 770 HSDFSRQDRF 780 HDFDHRDRGR 790 YPNHSVDRRE 800 GSRSMMGDRE 810 GQHYPERHGG 820 PERHGRDSRD 830 GWGYGSNKRL 840 SEGRGLPLLP 850 RRDWGEHARR 860 LEDDRAWQGT 870 ADGGMMERDQ 880 QRWQGGERSM 890 SGHSGPGHMM 900 NRGGMSGRGS 910 FAPGGASRRH 920 VIPRGGMQAG 930 FGGTEPGQQT Q

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030496 midbody
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0043565 sequence-specific DNA binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0030520 estrogen receptor signaling pathway
Biological Process GO:0042445 hormone metabolic process
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0040008 regulation of growth
Biological Process GO:0050684 regulation of mRNA processing
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.