Overview
| Uniprot ID | O88544 |
|---|
| Protein Name | COP9 signalosome complex subunit 4 |
|---|
| Gene Name | Cops4 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 20 |
MNSSGSHKDLAGKYR |
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity)
Protein Sequence
10
MAAAVRQDLA
20
QLMNSSGSHK
30
DLAGKYRQIL
40
EKAIQLSGTE
50
QLEALKAFVE
60
AMVNENVSLV
70
ISRQLLTDFC
80
THLPNLPDST
90
AKEVYHFTLE
100
KIQPRVISFE
110
EQVASIRQHL
120
ASIYEKEEDW
130
RNAAQVLVGI
140
PLETGQKQYN
150
VDYKLETYLK
160
IARLYLEDDD
170
PVQAEAYINR
180
ASLLQNESTN
190
EQLQIHYKVC
200
YARVLDYRRK
210
FIEAAQRYNE
220
LSYKTIVHES
230
ERLEALKHAL
240
HCTILASAGQ
250
QRSRMLATLF
260
KDERCQQLAA
270
YGILEKMYLD
280
RIIRGNQLQE
290
FAAMLMPHQK
300
ATTADGSSIL
310
DRAVIEHNLL
320
SASKLYNNIT
330
FEELGALLEI
340
PAAKAEKIAS
350
QMITEGRMNG
360
FIDQIDGIVH
370
FETREALPTW
380
DKQIQSLCFQ
390
VNNLLEKISQ
400
TAPEWTAQAM
EAQMAQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030054 |
cell junction |
| Cellular Component |
GO:0008180 |
COP9 signalosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0008021 |
synaptic vesicle |
| Biological Process |
GO:0000338 |
protein deneddylation |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.