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Overview

Uniprot IDO88588
Protein NamePhosphofurin acidic cluster sorting protein 1
Gene NamePacs1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
424 NSKGSLGKDTTSPME
485 KTPMKSSKADLQGSA
496 QGSASPSKVEGTHTP
518 LKERQLSKPLSERTN

Function

Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (By similarity)

Protein Sequence

10 MAERGGAGGG 20 PGGAGGGSSQ 30 RGSGVAQSPQ 40 QQPPQQPSQP 50 QQPTPPKLAQ 60 ATSSSSSTSA 70 AAASSSSSST 80 STSMAVAVAS 90 GSAPPGGPGP 100 GRTPAPVQMN 110 LYATWEVDRS 120 SSSCVPRLFS 130 LTLKKLVMLK 140 EMDKDLNSVV 150 IAVKLQGSKR 160 ILRSNEIILP 170 ASGLVETELQ 180 LTFSLQYPHF 190 LKRDANKLQI 200 MLQRRKRYKN 210 RTILGYKTLA 220 VGLINMAEVM 230 QHPNEGALVL 240 GLHSNVKDVS 250 VPVAEIKIYS 260 LSSQPIDHEG 270 IKSKLSDRSP 280 DIDNYSEEEE 290 ESFSSEQEGS 300 DDPLHGQDLF 310 YEDEDLRKVK 320 KTRRKLTSTS 330 AITRQPNIKQ 340 KFVALLKRFK 350 VSDEVGFGLE 360 HVSREQIREV 370 EEDLDELYDS 380 LEMYNPSDSG 390 PEMEETESIL 400 STPKPKLKPF 410 FEGMSQSSSQ 420 TEIGSLNSKG 430 SLGKDTTSPM 440 ELAALEKVKS 450 TWIKNQDDSL 460 TETDTLEITD 470 QDMFGDASTS 480 LVVPEKVKTP 490 MKSSKADLQG 500 SASPSKVEGT 510 HTPRQKRSTP 520 LKERQLSKPL 530 SERTNSSDSE 540 RSPDLGHSTQ 550 IPRKVVYDQL 560 NQILVSDAAL 570 PENVILVNTT 580 DWQGQYVAEL 590 LQDQRKPVVC 600 TCSTVEVQAV 610 LSALLTRIQR 620 YCNCNSSMPR 630 PVKVAAVGSQ 640 SYLSSILRFF 650 VKSLASKTPD 660 WLGHMRFLIV 670 PLGSHPVAKY 680 LGSVDSRYSS 690 TFLDSAWRDL 700 FSRSEPPVSE 710 PLDVVGRVMQ 720 YVNGATTTHQ 730 LPVAEAMLTC 740 RHKFPDEDSY 750 QKFIPFIGVV 760 KVGLVEDSPS 770 TAGDGDDSPV 780 VSLTVPSTSP 790 PSSSGLSRDA 800 TATPPSSPSM 810 SSALAIVGSP 820 NSPYGDVIGL 830 QVDYWLGHPG 840 ERRREGDKRD 850 ASSKNTLKSV 860 FRSVQVSRLP 870 HAGEAQLSGT 880 MAMTVVTKEK 890 NKKVPTIFLS 900 KKPREKEVDS 910 KSQVIEGISR 920 LICSAKQQQT 930 MLRVSIDGVE 940 WSDIKFFQLA 950 AQWPTHVKHF 960 PVGLFSGSKP T

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030137 COPI-coated vesicle
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0044325 transmembrane transporter binding
Biological Process GO:0002260 lymphocyte homeostasis
Biological Process GO:0034067 protein localization to Golgi apparatus
Biological Process GO:0072659 protein localization to plasma membrane

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.