Search Results

Overview

Uniprot IDO88600
Protein NameHeat shock 70 kDa protein 4
Gene NameHspa4
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
126 AMLLSKLKETAESVL
388 AILSPAFKVREFSIT
53 RSVGAAAKSQVISNA
557 ETSQAGSKDKKMDQP
560 QAGSKDKKMDQPPQA
568 MDQPPQAKKAKVKTS
573 QAKKAKVKTSTVDLP
609 GKMIMQDKLEKERND
61 SQVISNAKNTVQGFK
773 KEIEAKIKELTNICS
785 ICSPIISKPKPKVEP
789 IISKPKPKVEPPKEE

Function

No function data available.

Protein Sequence

10 MSVVGIDLGF 20 QSCYVAVARA 30 GGIETIANEY 40 SDRCTPACVS 50 FGPKNRSVGA 60 AAKSQVISNA 70 KNTVQGFKRF 80 HGRAFSDPFV 90 EAEKSNLAYD 100 IVQLPTGLTG 110 IKVTYMEEER 120 NFTTEQVTAM 130 LLSKLKETAE 140 SVLKKPVVDC 150 VVSVPSFYTD 160 AERRSVMDAT 170 QIAGLNCLRL 180 MNETTAVALA 190 YGIYKQDLPA 200 LEEKPRNVVF 210 VDMGHSAYQV 220 SVCAFNRGKL 230 KVLATAFDTT 240 LGGRKFDEVL 250 VNHFCEEFGK 260 KYKLDIKSKV 270 RALLRLSQEC 280 EKLKKLMSAN 290 ASDLPLSIEC 300 FMNDIDVSGT 310 MNRGKFLEMC 320 DDLLARVEPP 330 LRSILDQSKL 340 KKEDIYAVEI 350 VGGATRIPAV 360 KEKISKFFGK 370 ELSTTLNADE 380 AVTRGCALQC 390 AILSPAFKVR 400 EFSITDVVPY 410 PISLRWNSPA 420 EEGSSDCEVF 430 PKNHAAPFSK 440 VLTFYRKEPF 450 TLEAYYSSPQ 460 DLPYPDPAIA 470 QFSVQKVTPQ 480 SDGSSSKVKV 490 KVRVNVHGIF 500 SVSSAALVEV 510 HKSEESEEPM 520 ETDQNAKEEE 530 KMQVDQEEPH 540 TEEQQPQTPA 550 ENKAESEEME 560 TSQAGSKDKK 570 MDQPPQAKKA 580 KVKTSTVDLP 590 IESQLLWQLD 600 REMLGLYTEN 610 EGKMIMQDKL 620 EKERNDAKNA 630 VEEYVYEMRD 640 KLSGEYEKFV 650 SEDDRNNFTL 660 KLEDTENWLY 670 EDGEDQPKQV 680 YVDKLAELRT 690 LGQPIKTRFQ 700 ESEERPKLFE 710 ELGKQIQQYM 720 KVISSFKNKE 730 DQYEHLDAAD 740 MTKVEKSTNE 750 AMEWMNSKLN 760 LQNKQSLTAD 770 PVVKTKEIEA 780 KIKELTNICS 790 PIISKPKPKV 800 EPPKEEPKHA 810 EQNGPVDGQG 820 DNPGTQAAEH 830 GADTAVPSDG 840 DKKLPEMDID

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005811 lipid droplet
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000774 adenyl-nucleotide exchange factor activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Biological Process GO:0051131 chaperone-mediated protein complex assembly
Biological Process GO:0001822 kidney development
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:0051402 neuron apoptotic process
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0006457 protein folding
Biological Process GO:0030150 protein import into mitochondrial matrix
Biological Process GO:1903978 regulation of microglial cell activation

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.