Overview
| Uniprot ID | O88656 |
|---|
| Protein Name | Actin-related protein 2/3 complex subunit 1B |
|---|
| Gene Name | Arpc1b |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 307 |
ERFQNLDKKASSEGG |
| 308 |
RFQNLDKKASSEGGA |
Function
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)
Protein Sequence
10
MAYHSFLVEP
20
ISCHAWNKDR
30
TQIAICPNNH
40
EVHIYEKSGA
50
KWNKVHELKE
60
HNGQVTGIDW
70
APESNRIVTC
80
GTDRNAYVWT
90
LKGRTWKPTL
100
VILRINRAAR
110
CVRWAPNENK
120
FAVGSGSRVI
130
SICYFEQEND
140
WWVCKHIKKP
150
IRSTVLSLDW
160
HPNNVLLAAG
170
SCDFKCRIFS
180
AYIKEVEERP
190
APTPWGSKMP
200
FGELMFESSS
210
SCGWVHGVCF
220
SAGGSRVAWV
230
SHDSTVCLVD
240
AEKKMAVATL
250
ASETLPLLAI
260
TFITENSLVA
270
AGHDCFPVLF
280
TYDNAAGTLS
290
FGGRLDVPKQ
300
NSQRGLTARE
310
RFQNLDKKAS
320
SEGGAATGAG
330
LDSLHKNSVS
340
QISVLSGGKA
350
KCSQFCTTGM
360
DGGMSIWDVK
370
SLESALKDLK
IR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005885 |
Arp2/3 protein complex |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0036284 |
tubulobulbar complex |
| Molecular Function |
GO:0051015 |
actin filament binding |
| Molecular Function |
GO:0044877 |
protein-containing complex binding |
| Molecular Function |
GO:0005200 |
structural constituent of cytoskeleton |
| Biological Process |
GO:0034314 |
Arp2/3 complex-mediated actin nucleation |
| Biological Process |
GO:0032355 |
response to estradiol |
| Biological Process |
GO:0043627 |
response to estrogen |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.