Search Results
Overview
| Uniprot ID | O88990 |
|---|---|
| Protein Name | Alpha-actinin-3 |
| Gene Name | Actn3 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | KGKMRFHKIANVNKA |
| 208 | PDLIDYAKLRKDDPI |
| 245 | EDIVNTPKPDEKAIM |
| 277 | TAANRICKVLAVNQE |
| 287 | AVNQENEKLMEEYEK |
| 411 | RLQHLAEKFQQKASL |
| 415 | LAEKFQQKASLHEAW |
| 48 | AWEKQQRKTFTAWCN |
| 600 | QTYGLRPKSGNPYIT |
| 717 | ESLVFDNKHTVYSME |
| 754 | QVLTRDAKGLSQEQL |
Function
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity)
Protein Sequence
10
MMMVMQPEGL
20
GAGEGPFSGG
30
GGGEYMEQEE
40
DWDRDLLLDP
50
AWEKQQRKTF
60
TAWCNSHLRK
70
AGTQIENIEE
80
DFRNGLKLML
90
LLEVISGERL
100
PRPDKGKMRF
110
HKIANVNKAL
120
DFIASKGVKL
130
VSIGAEEIVD
140
GNLKMTLGMI
150
WTIILRFAIQ
160
DISVEETSAK
170
EGLLLWCQRK
180
TAPYRNVNVQ
190
NFHTSWKDGL
200
ALCALIHRHR
210
PDLIDYAKLR
220
KDDPIGNLNT
230
AFEVAEKYLD
240
IPKMLDAEDI
250
VNTPKPDEKA
260
IMTYVSCFYH
270
AFAGAEQAET
280
AANRICKVLA
290
VNQENEKLME
300
EYEKLASELL
310
EWIRRTVPWL
320
ENRVGEPSMS
330
AMQRKLEDFR
340
DYRRLHKPPR
350
VQEKCQLEIN
360
FNTLQTKLRL
370
SHRPAFMPSE
380
GKLVSDIANA
390
WRGLEQVEKG
400
YEDWLLSEIR
410
RLQRLQHLAE
420
KFQQKASLHE
430
AWTRGKEEML
440
NQHDYESASL
450
QEVRALLRRH
460
EAFESDLAAH
470
QDRVEHIAAL
480
AQELNELDYH
490
EAASVNSRCQ
500
AICDQWDNLG
510
TLTQKRRDAL
520
ERMEKLLETI
530
DQLQLEFARR
540
AAPFNNWLDG
550
AIEDLQDVWL
560
VHSVEETQSL
570
LTAHEQFKAT
580
LPEADRERGA
590
ILGIQGEIQK
600
ICQTYGLRPK
610
SGNPYITLSS
620
QDINNKWDTV
630
RKLVPSRDQT
640
LQEELARQQV
650
NERLRRQFAA
660
QANAIGPWIQ
670
GKVEEVGRLA
680
AGLAGSLEEQ
690
MAGLRQQEQN
700
IINYKSNIDR
710
LEGDHQLLQE
720
SLVFDNKHTV
730
YSMEHIRVGW
740
EQLLTSIART
750
INEVENQVLT
760
RDAKGLSQEQ
770
LNEFRASFNH
780
FDRKRNGMME
790
PDDFRACLIS
800
MGYDLGEVEF
810
ARIMTMVDPN
820
AAGVVTFQAF
830
IDFMTRETAE
840
TDTAEQVVAS
850
FKILAGDKNY
860
ITPEELRREL
870
PAEQAEYCIR
880
RMAPYKGSGA
890
PSGALDYVAF
900
SSALYGESDL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0014728 | regulation of the force of skeletal muscle contraction |
| Biological Process | GO:0014894 | response to denervation involved in regulation of muscle adaptation |
| Biological Process | GO:0014732 | skeletal muscle atrophy |
| Biological Process | GO:0014883 | transition between fast and slow fiber |
| Cellular Component | GO:0005903 | brush border |
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0042995 | cell projection |
| Cellular Component | GO:0030864 | cortical actin cytoskeleton |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0030017 | sarcomere |
| Cellular Component | GO:0005865 | striated muscle thin filament |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0060349 | bone morphogenesis |
| Biological Process | GO:0048041 | focal adhesion assembly |
| Biological Process | GO:0055001 | muscle cell development |
| Biological Process | GO:0006936 | muscle contraction |
| Biological Process | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade |
| Biological Process | GO:0120163 | negative regulation of cold-induced thermogenesis |
| Biological Process | GO:0045820 | negative regulation of glycolytic process |
| Biological Process | GO:0090324 | negative regulation of oxidative phosphorylation |
| Biological Process | GO:1901078 | negative regulation of relaxation of muscle |
| Biological Process | GO:1900159 | positive regulation of bone mineralization involved in bone maturation |
| Biological Process | GO:0031448 | positive regulation of fast-twitch skeletal muscle fiber contraction |
| Biological Process | GO:1904025 | positive regulation of glucose catabolic process to lactate via pyruvate |
| Biological Process | GO:0048743 | positive regulation of skeletal muscle fiber development |
| Biological Process | GO:0048633 | positive regulation of skeletal muscle tissue growth |
| Biological Process | GO:1903715 | regulation of aerobic respiration |
| Biological Process | GO:0090257 | regulation of muscle system process |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.