Search Results
Overview
| Uniprot ID | O89046 |
|---|---|
| Protein Name | Coronin-1B |
| Gene Name | Coro1b |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 400 | REAYVPSKQRDLKVS |
| 416 | RNVLSDSKPAGYSRS |
| 463 | RALRVLVKEQGERIS |
Function
Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity)
Protein Sequence
10
MSFRKVVRQS
20
KFRHVFGQPV
30
KNDQCYEDIR
40
VSRVTWDSTF
50
CAVNPKFLAV
60
IVEASGGGAF
70
MVLPLNKTGR
80
IDKAYPTVCG
90
HTGPVLDIDW
100
CPHNDEVIAS
110
GSEDCTVMVW
120
QIPENGLTSP
130
LTEPVVVLEG
140
HTKRVGIITW
150
HPTARNVLLS
160
AGCDNVVLIW
170
NVGTAEELYR
180
LDSLHPDLIY
190
NVSWNHNGSL
200
FCTACKDKSV
210
RIIDPRRGTL
220
VAEREKAHEG
230
ARPMRAIFLA
240
DGKVFTAGFS
250
RMSERQLALW
260
DPENFEEPMA
270
LQELDSSNGA
280
LLPFYDPDTS
290
VVYVCGKGDS
300
SIRYFEITDE
310
PPYIHFLNTF
320
TSKEPQRGMG
330
SMPKRGLEVS
340
KCEIARFYKL
350
HERKCEPIVM
360
TVPRKSDLFQ
370
DDLYPDTAGP
380
DAALEAEDWV
390
SGQDADPILI
400
SLREAYVPSK
410
QRDLKVSRRN
420
VLSDSKPAGY
430
SRSGVSTATA
440
ITDIPSGNLA
450
GSGEAGKLEE
460
VMHGLRALRV
470
LVKEQGERIS
480
RLEEHLGRME
NGDT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0031252 | cell leading edge |
| Cellular Component | GO:0071944 | cell periphery |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0001725 | stress fiber |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0071933 | Arp2/3 complex binding |
| Molecular Function | GO:0008092 | cytoskeletal protein binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0090135 | actin filament branching |
| Biological Process | GO:0051017 | actin filament bundle assembly |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0036120 | cellular response to platelet-derived growth factor stimulus |
| Biological Process | GO:0035767 | endothelial cell chemotaxis |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation |
| Biological Process | GO:2000393 | negative regulation of lamellipodium morphogenesis |
| Biological Process | GO:0071672 | negative regulation of smooth muscle cell chemotaxis |
| Biological Process | GO:2000394 | positive regulation of lamellipodium morphogenesis |
| Biological Process | GO:1902463 | protein localization to cell leading edge |
| Biological Process | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation |
| Biological Process | GO:0031529 | ruffle organization |
| Biological Process | GO:0042060 | wound healing |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.