Search Results

Overview

Uniprot IDO94760
Protein NameN(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Gene NameDDAH1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
144 EFFVGLSKRTNQRGA
199 ESAQKALKIMQQMSD
211 MSDHRYDKLTVPDDI
247 EEYPESAKVYEKLKD
253 AKVYEKLKDHMLIPV
281 CCSVLINKKVDS***
34 QHALRSAKGEEVDVA

Function

Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation

Protein Sequence

10 MAGLGHPAAF 20 GRATHAVVRA 30 LPESLGQHAL 40 RSAKGEEVDV 50 ARAERQHQLY 60 VGVLGSKLGL 70 QVVELPADES 80 LPDCVFVEDV 90 AVVCEETALI 100 TRPGAPSRRK 110 EVDMMKEALE 120 KLQLNIVEMK 130 DENATLDGGD 140 VLFTGREFFV 150 GLSKRTNQRG 160 AEILADTFKD 170 YAVSTVPVAD 180 GLHLKSFCSM 190 AGPNLIAIGS 200 SESAQKALKI 210 MQQMSDHRYD 220 KLTVPDDIAA 230 NCIYLNIPNK 240 GHVLLHRTPE 250 EYPESAKVYE 260 KLKDHMLIPV 270 SMSELEKVDG 280 LLTCCSVLIN KKVDS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Biological Process GO:0043116 negative regulation of vascular permeability
Biological Process GO:0007263 nitric oxide mediated signal transduction
Biological Process GO:0046209 nitric oxide metabolic process
Biological Process GO:0045766 positive regulation of angiogenesis
Biological Process GO:0045429 positive regulation of nitric oxide biosynthetic process
Biological Process GO:0003073 regulation of systemic arterial blood pressure
Cellular Component GO:0070062 extracellular exosome
Molecular Function GO:0016597 amino acid binding
Molecular Function GO:0003824 catalytic activity
Molecular Function GO:0016403 dimethylargininase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0030235 nitric-oxide synthase regulator activity
Biological Process GO:0006525 arginine metabolic process
Biological Process GO:0000052 citrulline metabolic process
Biological Process GO:0006527 L-arginine catabolic process
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:1900038 negative regulation of cellular response to hypoxia

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.