Search Results

Overview

Uniprot ID	O94763
Protein Name	Unconventional prefoldin RPB5 interactor 1
Gene Name	URI1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
352	RVRINTGKNTTLKFS
357	TGKNTTLKFSEKKEE
370	EEAKRKRKNSTGSGH

Function

Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein

Protein Sequence

10 MEAPTVETPP 20 DPSPPSAPAP 30 ALVPLRAPDV 40 ARLREEQEKV 50 VTNCQERIQH 60 WKKVDNDYNA 70 LRERLSTLPD 80 KLSYNIMVPF 90 GPFAFMPGKL 100 VHTNEVTVLL 110 GDNWFAKCSA 120 KQAVGLVEHR 130 KEHVRKTIDD 140 LKKVMKNFES 150 RVEFTEDLQK 160 MSDAAGDIVD 170 IREEIKCDFE 180 FKAKHRIAHK 190 PHSKPKTSDI 200 FEADIANDVK 210 SKDLLADKEL 220 WARLEELERQ 230 EELLGELDSK 240 PDTVIANGED 250 TTSSEEEKED 260 RNTNVNAMHQ 270 VTDSHTPCHK 280 DVASSEPFSG 290 QVNSQLNCSV 300 NGSSSYHSDD 310 DDDDDDDDDD 320 DNIDDDDGDN 330 DHEALGVGDN 340 SIPTIYFSHT 350 VEPKRVRINT 360 GKNTTLKFSE 370 KKEEAKRKRK 380 NSTGSGHSAQ 390 ELPTIRTPAD 400 IYRAFVDVVN 410 GEYVPRKSIL 420 KSRSRENSVC 430 SDTSESSAAE 440 FDDRRGVLRS 450 ISCEEATCSD 460 TSESILEEEP 470 QENQKKLLPL 480 SVTPEAFSGT 490 VIEKEFVSPS 500 LTPPPAIAHP 510 ALPTIPERKE 520 VLLEASEETG 530 KRVSKFKAAR LQQKD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0032991	protein-containing complex
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0019212	phosphatase inhibitor activity
Molecular Function	GO:0051219	phosphoprotein binding
Molecular Function	GO:0004864	protein phosphatase inhibitor activity
Molecular Function	GO:0000993	RNA polymerase II complex binding
Molecular Function	GO:0003714	transcription corepressor activity
Biological Process	GO:0071363	cellular response to growth factor stimulus
Biological Process	GO:0071383	cellular response to steroid hormone stimulus
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Biological Process	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway
Biological Process	GO:0010923	negative regulation of phosphatase activity
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0050821	protein stabilization
Biological Process	GO:0001558	regulation of cell growth
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0009615	response to virus

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.