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Overview

Uniprot IDO94782
Protein NameUbiquitin carboxyl-terminal hydrolase 1
Gene NameUSP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
333 ESPRPSQKKSRVKIN
334 SPRPSQKKSRVKINW
343 RVKINWLKSATKQPS
360 SKFCSLGKITTNQGV
661 PSKVLNKKNVEAIGL
675 LLGGQKSKADYELYN

Function

Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029)

Protein Sequence

10 MPGVIPSESN 20 GLSRGSPSKK 30 NRLSLKFFQK 40 KETKRALDFT 50 DSQENEEKAS 60 EYRASEIDQV 70 VPAAQSSPIN 80 CEKRENLLPF 90 VGLNNLGNTC 100 YLNSILQVLY 110 FCPGFKSGVK 120 HLFNIISRKK 130 EALKDEANQK 140 DKGNCKEDSL 150 ASYELICSLQ 160 SLIISVEQLQ 170 ASFLLNPEKY 180 TDELATQPRR 190 LLNTLRELNP 200 MYEGYLQHDA 210 QEVLQCILGN 220 IQETCQLLKK 230 EEVKNVAELP 240 TKVEEIPHPK 250 EEMNGINSIE 260 MDSMRHSEDF 270 KEKLPKGNGK 280 RKSDTEFGNM 290 KKKVKLSKEH 300 QSLEENQRQT 310 RSKRKATSDT 320 LESPPKIIPK 330 YISENESPRP 340 SQKKSRVKIN 350 WLKSATKQPS 360 ILSKFCSLGK 370 ITTNQGVKGQ 380 SKENECDPEE 390 DLGKCESDNT 400 TNGCGLESPG 410 NTVTPVNVNE 420 VKPINKGEEQ 430 IGFELVEKLF 440 QGQLVLRTRC 450 LECESLTERR 460 EDFQDISVPV 470 QEDELSKVEE 480 SSEISPEPKT 490 EMKTLRWAIS 500 QFASVERIVG 510 EDKYFCENCH 520 HYTEAERSLL 530 FDKMPEVITI 540 HLKCFAASGL 550 EFDCYGGGLS 560 KINTPLLTPL 570 KLSLEEWSTK 580 PTNDSYGLFA 590 VVMHSGITIS 600 SGHYTASVKV 610 TDLNSLELDK 620 GNFVVDQMCE 630 IGKPEPLNEE 640 EARGVVENYN 650 DEEVSIRVGG 660 NTQPSKVLNK 670 KNVEAIGLLG 680 GQKSKADYEL 690 YNKASNPDKV 700 ASTAFAENRN 710 SETSDTTGTH 720 ESDRNKESSD 730 QTGINISGFE 740 NKISYVVQSL 750 KEYEGKWLLF 760 DDSEVKVTEE 770 KDFLNSLSPS 780 TSPTSTPYLL FYKKL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0004843 cysteine-type deubiquitinase activity
Molecular Function GO:0004197 cysteine-type endopeptidase activity
Molecular Function GO:0008233 peptidase activity
Biological Process GO:0006281 DNA repair
Biological Process GO:0035520 monoubiquitinated protein deubiquitination
Biological Process GO:1904333 positive regulation of error-prone translesion synthesis
Biological Process GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0006508 proteolysis
Biological Process GO:0006282 regulation of DNA repair
Biological Process GO:0031647 regulation of protein stability
Biological Process GO:0009411 response to UV

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.