Search Results
Overview
| Uniprot ID | O94804 |
|---|---|
| Protein Name | Serine/threonine-protein kinase 10 |
| Gene Name | STK10 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 605 | FEQEINAKKKFFDTE |
| 606 | EQEINAKKKFFDTEL |
| 958 | STPSKAAKFFPYSSA |
Function
Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo
Protein Sequence
10
MAFANFRRIL
20
RLSTFEKRKS
30
REYEHVRRDL
40
DPNEVWEIVG
50
ELGDGAFGKV
60
YKAKNKETGA
70
LAAAKVIETK
80
SEEELEDYIV
90
EIEILATCDH
100
PYIVKLLGAY
110
YHDGKLWIMI
120
EFCPGGAVDA
130
IMLELDRGLT
140
EPQIQVVCRQ
150
MLEALNFLHS
160
KRIIHRDLKA
170
GNVLMTLEGD
180
IRLADFGVSA
190
KNLKTLQKRD
200
SFIGTPYWMA
210
PEVVMCETMK
220
DTPYDYKADI
230
WSLGITLIEM
240
AQIEPPHHEL
250
NPMRVLLKIA
260
KSDPPTLLTP
270
SKWSVEFRDF
280
LKIALDKNPE
290
TRPSAAQLLE
300
HPFVSSITSN
310
KALRELVAEA
320
KAEVMEEIED
330
GRDEGEEEDA
340
VDAASTLENH
350
TQNSSEVSPP
360
SLNADKPLEE
370
SPSTPLAPSQ
380
SQDSVNEPCS
390
QPSGDRSLQT
400
TSPPVVAPGN
410
ENGLAVPVPL
420
RKSRPVSMDA
430
RIQVAQEKQV
440
AEQGGDLSPA
450
ANRSQKASQS
460
RPNSSALETL
470
GGEKLANGSL
480
EPPAQAAPGP
490
SKRDSDCSSL
500
CTSESMDYGT
510
NLSTDLSLNK
520
EMGSLSIKDP
530
KLYKKTLKRT
540
RKFVVDGVEV
550
SITTSKIISE
560
DEKKDEEMRF
570
LRRQELRELR
580
LLQKEEHRNQ
590
TQLSNKHELQ
600
LEQMHKRFEQ
610
EINAKKKFFD
620
TELENLERQQ
630
KQQVEKMEQD
640
HAVRRREEAR
650
RIRLEQDRDY
660
TRFQEQLKLM
670
KKEVKNEVEK
680
LPRQQRKESM
690
KQKMEEHTQK
700
KQLLDRDFVA
710
KQKEDLELAM
720
KRLTTDNRRE
730
ICDKERECLM
740
KKQELLRDRE
750
AALWEMEEHQ
760
LQERHQLVKQ
770
QLKDQYFLQR
780
HELLRKHEKE
790
REQMQRYNQR
800
MIEQLKVRQQ
810
QEKARLPKIQ
820
RSEGKTRMAM
830
YKKSLHINGG
840
GSAAEQREKI
850
KQFSQQEEKR
860
QKSERLQQQQ
870
KHENQMRDML
880
AQCESNMSEL
890
QQLQNEKCHL
900
LVEHETQKLK
910
ALDESHNQNL
920
KEWRDKLRPR
930
KKALEEDLNQ
940
KKREQEMFFK
950
LSEEAECPNP
960
STPSKAAKFF
PYSSADAS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0035579 | specific granule membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0071593 | lymphocyte aggregation |
| Biological Process | GO:0046777 | protein autophosphorylation |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:2000401 | regulation of lymphocyte migration |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.