Search Results
Overview
| Uniprot ID | O94811 |
|---|---|
| Protein Name | Tubulin polymerization-promoting protein |
| Gene Name | TPPP |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 147 | VHRLIEGKAPIISGV |
| 156 | PIISGVTKAISSPTV |
| 17 | AANRTPPKSPGDPSK |
| 171 | SRLTDTTKFTGSHKE |
| 185 | ERFDPSGKGKGKAGR |
| 187 | FDPSGKGKGKAGRVD |
| 206 | SGYVSGYKHAGTYDQ |
| 214 | HAGTYDQKVQGGK** |
| 4 | ****MADKAKPAKAA |
| 81 | KNWSKLCKDCQVIDG |
Function
Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887, PubMed:33831707). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed:21316364, PubMed:21995432). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:17105200, PubMed:17693641, PubMed:18028908, PubMed:26289831). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed:20308065, PubMed:23093407). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed:23093407). Plays a role in cell proliferation by regulating the G1/S-phase transition (PubMed:23355470). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed:22328514)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005815 | microtubule organizing center |
| Cellular Component | GO:0072686 | mitotic spindle |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0150051 | postsynaptic Golgi apparatus |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0015631 | tubulin binding |
| Biological Process | GO:0030953 | astral microtubule organization |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0001578 | microtubule bundle formation |
| Biological Process | GO:0051418 | microtubule nucleation by microtubule organizing center |
| Biological Process | GO:0046785 | microtubule polymerization |
| Biological Process | GO:0032288 | myelin assembly |
| Biological Process | GO:1904428 | negative regulation of tubulin deacetylation |
| Biological Process | GO:0014003 | oligodendrocyte development |
| Biological Process | GO:0048709 | oligodendrocyte differentiation |
| Biological Process | GO:0031643 | positive regulation of myelination |
| Biological Process | GO:0032273 | positive regulation of protein polymerization |
| Biological Process | GO:0031334 | positive regulation of protein-containing complex assembly |
| Biological Process | GO:0070507 | regulation of microtubule cytoskeleton organization |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.