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Overview

Uniprot IDO94826
Protein NameMitochondrial import receptor subunit TOM70
Gene NameTOMM70
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
168 AAFEQLQKWKEVAQD
185 KAVELNPKYVKALFR
312 MEEENYDKIISECSK
359 LDKVISLKEANVKLR
470 KGFEEVIKKFPRCAE
524 GLLQLQWKQDLDRGL

Function

Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812)

Protein Sequence

10 MAASKPVEAA 20 VVAAAVPSSG 30 SGVGGGGTAG 40 PGTGGLPRWQ 50 LALAVGAPLL 60 LGAGAIYLWS 70 RQQRRREARG 80 RGDASGLKRN 90 SERKTPEGRA 100 SPAPGSGHPE 110 GPGAHLDMNS 120 LDRAQAAKNK 130 GNKYFKAGKY 140 EQAIQCYTEA 150 ISLCPTEKNV 160 DLSTFYQNRA 170 AAFEQLQKWK 180 EVAQDCTKAV 190 ELNPKYVKAL 200 FRRAKAHEKL 210 DNKKECLEDV 220 TAVCILEGFQ 230 NQQSMLLADK 240 VLKLLGKEKA 250 KEKYKNREPL 260 MPSPQFIKSY 270 FSSFTDDIIS 280 QPMLKGEKSD 290 EDKDKEGEAL 300 EVKENSGYLK 310 AKQYMEEENY 320 DKIISECSKE 330 IDAEGKYMAE 340 ALLLRATFYL 350 LIGNANAAKP 360 DLDKVISLKE 370 ANVKLRANAL 380 IKRGSMYMQQ 390 QQPLLSTQDF 400 NMAADIDPQN 410 ADVYHHRGQL 420 KILLDQVEEA 430 VADFDECIRL 440 RPESALAQAQ 450 KCFALYRQAY 460 TGNNSSQIQA 470 AMKGFEEVIK 480 KFPRCAEGYA 490 LYAQALTDQQ 500 QFGKADEMYD 510 KCIDLEPDNA 520 TTYVHKGLLQ 530 LQWKQDLDRG 540 LELISKAIEI 550 DNKCDFAYET 560 MGTIEVQRGN 570 MEKAIDMFNK 580 AINLAKSEME 590 MAHLYSLCDA 600 AHAQTEVAKK YGLKPPTL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Biological Process GO:0045039 protein insertion into mitochondrial inner membrane
Biological Process GO:0045040 protein insertion into mitochondrial outer membrane
Biological Process GO:0006626 protein targeting to mitochondrion
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:0097068 response to thyroxine
Cellular Component GO:0016020 membrane
Cellular Component GO:0031966 mitochondrial membrane
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005742 mitochondrial outer membrane translocase complex
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0030943 mitochondrion targeting sequence binding
Molecular Function GO:0008320 protein transmembrane transporter activity
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Biological Process GO:0002218 activation of innate immune response
Biological Process GO:0098586 cellular response to virus
Biological Process GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
Biological Process GO:0002230 positive regulation of defense response to virus by host
Biological Process GO:0032728 positive regulation of interferon-beta production
Biological Process GO:1903955 positive regulation of protein targeting to mitochondrion
Biological Process GO:0030150 protein import into mitochondrial matrix

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.