Search Results
Overview
| Uniprot ID | O94832 |
|---|---|
| Protein Name | Unconventional myosin-Id |
| Gene Name | MYO1D |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 559 | LSITEVTKRPLTAAT |
| 94 | KAMKRRSKDTCIVIS |
Function
Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity)
Protein Sequence
10
MAEQESLEFG
20
KADFVLMDTV
30
SMPEFMANLR
40
LRFEKGRIYT
50
FIGEVVVSVN
60
PYKLLNIYGR
70
DTIEQYKGRE
80
LYERPPHLFA
90
IADAAYKAMK
100
RRSKDTCIVI
110
SGESGAGKTE
120
ASKYIMQYIA
130
AITNPSQRAE
140
VERVKNMLLK
150
SNCVLEAFGN
160
AKTNRNDNSS
170
RFGKYMDINF
180
DFKGDPIGGH
190
INNYLLEKSR
200
VIVQQPGERS
210
FHSFYQLLQG
220
GSEQMLRSLH
230
LQKSLSSYNY
240
IHVGAQLKSS
250
INDAAEFRVV
260
ADAMKVIGFK
270
PEEIQTVYKI
280
LAAILHLGNL
290
KFVVDGDTPL
300
IENGKVVSII
310
AELLSTKTDM
320
VEKALLYRTV
330
ATGRDIIDKQ
340
HTEQEASYGR
350
DAFAKAIYER
360
LFCWIVTRIN
370
DIIEVKNYDT
380
TIHGKNTVIG
390
VLDIYGFEIF
400
DNNSFEQFCI
410
NYCNEKLQQL
420
FIQLVLKQEQ
430
EEYQREGIPW
440
KHIDYFNNQI
450
IVDLVEQQHK
460
GIIAILDDAC
470
MNVGKVTDEM
480
FLEALNSKLG
490
KHAHFSSRKL
500
CASDKILEFD
510
RDFRIRHYAG
520
DVVYSVIGFI
530
DKNKDTLFQD
540
FKRLMYNSSN
550
PVLKNMWPEG
560
KLSITEVTKR
570
PLTAATLFKN
580
SMIALVDNLA
590
SKEPYYVRCI
600
KPNDKKSPQI
610
FDDERCRHQV
620
EYLGLLENVR
630
VRRAGFAFRQ
640
TYEKFLHRYK
650
MISEFTWPNH
660
DLPSDKEAVK
670
KLIERCGFQD
680
DVAYGKTKIF
690
IRTPRTLFTL
700
EELRAQMLIR
710
IVLFLQKVWR
720
GTLARMRYKR
730
TKAALTIIRY
740
YRRYKVKSYI
750
HEVARRFHGV
760
KTMRDYGKHV
770
KWPSPPKVLR
780
RFEEALQTIF
790
NRWRASQLIK
800
SIPASDLPQV
810
RAKVAAVEML
820
KGQRADLGLQ
830
RAWEGNYLAS
840
KPDTPQTSGT
850
FVPVANELKR
860
KDKYMNVLFS
870
CHVRKVNRFS
880
KVEDRAIFVT
890
DRHLYKMDPT
900
KQYKVMKTIP
910
LYNLTGLSVS
920
NGKDQLVVFH
930
TKDNKDLIVC
940
LFSKQPTHES
950
RIGELVGVLV
960
NHFKSEKRHL
970
QVNVTNPVQC
980
SLHGKKCTVS
990
VETRLNQPQP
1000
DFTKNRSGFI
LSVPGN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0051015 | actin filament binding |
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0097440 | apical dendrite |
| Cellular Component | GO:0030673 | axolemma |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005903 | brush border |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005902 | microvillus |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0016459 | myosin complex |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0000146 | microfilament motor activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0030048 | actin filament-based movement |
| Biological Process | GO:0051641 | cellular localization |
| Biological Process | GO:0061502 | early endosome to recycling endosome transport |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0015031 | protein transport |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.