Search Results

Overview

Uniprot IDO94842
Protein NameTOX high mobility group box family member 4
Gene NameTOX4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
207 TVVVEAGKKQKAPKK
208 VVVEAGKKQKAPKKR

Function

Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (By similarity). In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1 (By similarity). This regulation is independent of the insulin receptor activation (By similarity). Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes (PubMed:39603239, PubMed:39603240). Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release (PubMed:39603239, PubMed:39603240). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061)

Protein Sequence

10 MEFPGGNDNY 20 LTITGPSHPF 30 LSGAETFHTP 40 SLGDEEFEIP 50 PISLDSDPSL 60 AVSDVVGHFD 70 DLADPSSSQD 80 GSFSAQYGVQ 90 TLDMPVGMTH 100 GLMEQGGGLL 110 SGGLTMDLDH 120 SIGTQYSANP 130 PVTIDVPMTD 140 MTSGLMGHSQ 150 LTTIDQSELS 160 SQLGLSLGGG 170 TILPPAQSPE 180 DRLSTTPSPT 190 SSLHEDGVED 200 FRRQLPSQKT 210 VVVEAGKKQK 220 APKKRKKKDP 230 NEPQKPVSAY 240 ALFFRDTQAA 250 IKGQNPNATF 260 GEVSKIVASM 270 WDSLGEEQKQ 280 VYKRKTEAAK 290 KEYLKALAAY 300 KDNQECQATV 310 ETVELDPAPP 320 SQTPSPPPMA 330 TVDPASPAPA 340 SIEPPALSPS 350 IVVNSTLSSY 360 VANQASSGAG 370 GQPNITKLII 380 TKQMLPSSIT 390 MSQGGMVTVI 400 PATVVTSRGL 410 QLGQTSTATI 420 QPSQQAQIVT 430 RSVLQAAAAA 440 AAAASMQLPP 450 PRLQPPPLQQ 460 MPQPPTQQQV 470 TILQQPPPLQ 480 AMQQPPPQKV 490 RINLQQQPPP 500 LQIKSVPLPT 510 LKMQTTLVPP 520 TVESSPERPM 530 NNSPEAHTVE 540 APSPETICEM 550 ITDVVPEVES 560 PSQMDVELVS 570 GSPVALSPQP 580 RCVRSGCENP 590 PIVSKDWDNE 600 YCSNECVVKH 610 CRDVFLAWVA 620 SRNSNTVVFV K

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005634 nucleus
Cellular Component GO:0072357 PTW/PP1 phosphatase complex
Molecular Function GO:0031490 chromatin DNA binding
Biological Process GO:0032968 positive regulation of transcription elongation by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0001111 RNA polymerase II promoter clearance

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.