Search Results

Overview

Uniprot IDO94875
Protein NameSorbin and SH3 domain-containing protein 2
Gene NameSORBS2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
258 SDFRKRRKSEPAVGP
863 ERRGTPEKEKLPAKA

Function

Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder

Protein Sequence

10 MSYYQRPFSP 20 SAYSLPASLN 30 SSIVMQHGTS 40 LDSTDTYPQH 50 AQSLDGTTSS 60 SIPLYRSSEE 70 EKRVTVIKAP 80 HYPGIGPVDE 90 SGIPTAIRTT 100 VDRPKDWYKT 110 MFKQIHMVHK 120 PDDDTDMYNT 130 PYTYNAGLYN 140 PPYSAQSHPA 150 AKTQTYRPLS 160 KSHSDNSPNA 170 FKDASSPVPP 180 PHVPPPVPPL 190 RPRDRSSTEK 200 HDWDPPDRKV 210 DTRKFRSEPR 220 SIFEYEPGKS 230 SILQHERPAS 240 LYQSSIDRSL 250 ERPMSSASMA 260 SDFRKRRKSE 270 PAVGPPRGLG 280 DQSASRTSPG 290 RVDLPGSSTT 300 LTKSFTSSSP 310 SSPSRAKGGD 320 DSKICPSLCS 330 YSGLNGNPSS 340 ELDYCSTYRQ 350 HLDVPRDSPR 360 AISFKNGWQM 370 ARQNAEIWSS 380 TEETVSPKIK 390 SRSCDDLLND 400 DCDSFPDPKV 410 KSESMGSLLC 420 EEDSKESCPM 430 AWGSPYVPEV 440 RSNGRSRIRH 450 RSARNAPGFL 460 KMYKKMHRIN 470 RKDLMNSEVI 480 CSVKSRILQY 490 ESEQQHKDLL 500 RAWSQCSTEE 510 VPRDMVPTRI 520 SEFEKLIQKS 530 KSMPNLGDDM 540 LSPVTLEPPQ 550 NGLCPKRRFS 560 IEYLLEEENQ 570 SGPPARGRRG 580 CQSNALVPIH 590 IEVTSDEQPR 600 AHVEFSDSDQ 610 DGVVSDHSDY 620 IHLEGSSFCS 630 ESDFDHFSFT 640 SSESFYGSSH 650 HHHHHHHHHH 660 RHLISSCKGR 670 CPASYTRFTT 680 MLKHERARHE 690 NTEEPRRQEM 700 DPGLSKLAFL 710 VSPVPFRRKK 720 NSAPKKQTEK 730 AKCKASVFEA 740 LDSALKDICD 750 QIKAEKKRGS 760 LPDNSILHRL 770 ISELLPDVPE 780 RNSSLRALRR 790 SPLHQPLHPL 800 PPDGAIHCPP 810 YQNDCGRMPR 820 SASFQDVDTA 830 NSSCHHQDRG 840 GALQDRESPR 850 SYSSTLTDMG 860 RSAPRERRGT 870 PEKEKLPAKA 880 VYDFKAQTSK 890 ELSFKKGDTV 900 YILRKIDQNW 910 YEGEHHGRVG 920 IFPISYVEKL 930 TPPEKAQPAR 940 PPPPAQPGEI 950 GEAIAKYNFN 960 ADTNVELSLR 970 KGDRVILLKR 980 VDQNWYEGKI 990 PGTNRQGIFP 1000 VSYVEVVKKN 1010 TKGAEDYPDP 1020 PIPHSYSSDR 1030 IHSLSSNKPQ 1040 RPVFTHENIQ 1050 GGGEPFQALY 1060 NYTPRNEDEL 1070 ELRESDVIDV 1080 MEKCDDGWFV 1090 GTSRRTKFFG 1100 TFPGNYVKRL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0030425 dendrite
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045202 synapse
Cellular Component GO:0030018 Z disc
Molecular Function GO:0008093 cytoskeletal anchor activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0008307 structural constituent of muscle
Biological Process GO:0061049 cell growth involved in cardiac muscle cell development
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0007219 Notch signaling pathway

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.