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Overview

Uniprot IDO94880
Protein NamePHD finger protein 14
Gene NamePHF14
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
820 QDVPPEPKKIPIRNT
821 DVPPEPKKIPIRNTR
98 SSEKQLIKMEKKEEE

Function

Histone-binding protein (PubMed:23688586). Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3) (By similarity). Represses PDGFRA expression, thus playing a role in regulation of mesenchymal cell proliferation (By similarity). Suppresses the expression of CDKN1A/p21 by reducing the level of trimethylation of histone H3 'Lys-4', leading to enhanced proliferation of germinal center B cells (By similarity)

Protein Sequence

10 MDRSSKRRQV 20 KPLAASLLEA 30 LDYDSSDDSD 40 FKVGDASDSE 50 GSGNGSEDAS 60 KDSGEGSCSD 70 SEENILEEEL 80 NEDIKVKEEQ 90 LKNSAEEEVL 100 SSEKQLIKME 110 KKEEEENGER 120 PRKKKEKEKE 130 KEKEKEKEKE 140 REKEKEKATV 150 SENVAASAAA 160 TTPATSPPAV 170 NTSPSVPTTT 180 TATEEQVSEP 190 KKWNLRRNRP 200 LLDFVSMEEL 210 NDMDDYDSED 220 DNDWRPTVVK 230 RKGRSASQKE 240 GSDGDNEDDE 250 DEGSGSDEDE 260 NDEGNDEDHS 270 SPASEGGCKK 280 KKSKVLSRNS 290 ADDEELTNDS 300 LTLSQSKSNE 310 DSLILEKSQN 320 WSSQKMDHIL 330 ICCVCLGDNS 340 EDADEIIQCD 350 NCGITVHEGC 360 YGVDGESDSI 370 MSSASENSTE 380 PWFCDACKCG 390 VSPSCELCPN 400 QDGIFKETDA 410 GRWVHIVCAL 420 YVPGVAFGDI 430 DKLRPVTLTE 440 MNYSKYGAKE 450 CSFCEDPRFA 460 RTGVCISCDA 470 GMCRAYFHVT 480 CAQKEGLLSE 490 AAAEEDIADP 500 FFAYCKQHAD 510 RLDRKWKRKN 520 YLALQSYCKM 530 SLQEREKQLS 540 PEAQARINAR 550 LQQYRAKAEL 560 ARSTRPQAWV 570 PREKLPRPLT 580 SSASAIRKLM 590 RKAELMGIST 600 DIFPVDNSDT 610 SSSVDGRRKH 620 KQPALTADFV 630 NYYFERNMRM 640 IQIQENMAEQ 650 KNIKDKLENE 660 QEKLHVEYNK 670 LCESLEELQN 680 LNGKLRSEGQ 690 GIWALLGRIT 700 GQKLNIPAIL 710 RAPKERKPSK 720 KEGGTQKTST 730 LPAVLYSCGI 740 CKKNHDQHLL 750 LLCDTCKLHY 760 HLGCLDPPLT 770 RMPRKTKNSY 780 WQCSECDQAG 790 SSDMEADMAM 800 ETLPDGTKRS 810 RRQIKEPVKF 820 VPQDVPPEPK 830 KIPIRNTRTR 840 GRKRSFVPEE 850 EKHEERVPRE 860 RRQRQSVLQK 870 KPKAEDLRTE 880 CATCKGTGDN 890 ENLVRCDECR 900 LCYHFGCLDP 910 PLKKSPKQTG 920 YGWICQECDS 930 SSSKEDENEA 940 ERKNISQELN MEQKNPKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0042393 histone binding
Molecular Function GO:0140566 histone reader activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0002314 germinal center B cell differentiation
Biological Process GO:0048286 lung alveolus development
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0072201 negative regulation of mesenchymal cell proliferation
Biological Process GO:2000791 negative regulation of mesenchymal cell proliferation involved in lung development
Biological Process GO:2000584 negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.