Overview
| Uniprot ID | O94886 |
|---|
| Protein Name | Mechanosensitive cation channel TMEM63A |
|---|
| Gene Name | TMEM63A |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 274 |
AKLIYLCKEKKKTEK |
Function
Mechanosensitive cation channel with low conductance and high activation threshold (PubMed:30382938, PubMed:31587869, PubMed:37543036). In contrast to TMEM63B, does not show phospholipid scramblase activity (PubMed:39716028). Acts as a regulator of lysosomal morphology by mediating lysosomal mechanosensitivity (By similarity). Important for the baby's first breath and respiration throughout life (PubMed:38127458). Upon lung inflation conducts cation currents in alveolar type 1 and 2 cells triggering lamellar body exocytosis and surfactant secretion into airspace (PubMed:38127458). Also acts as an osmosensitive cation channel preferentially activated by hypotonic stress (By similarity)
Protein Sequence
10
MMDSPFLELW
20
QSKAVSIREQ
30
LGLGDRPNDS
40
YCYNSAKNST
50
VLQGVTFGGI
60
PTVLLIDVSC
70
FLFLILVFSI
80
IRRRFWDYGR
90
IALVSEADSE
100
SRFQRLSSTS
110
SSGQQDFENE
120
LGCCPWLTAI
130
FRLHDDQILE
140
WCGEDAIHYL
150
SFQRHIIFLL
160
VVVSFLSLCV
170
ILPVNLSGDL
180
LDKDPYSFGR
190
TTIANLQTDN
200
DLLWLHTIFA
210
VIYLFLTVGF
220
MRHHTQSIKY
230
KEENLVRRTL
240
FITGLPRDAR
250
KETVESHFRD
260
AYPTCEVVDV
270
QLCYNVAKLI
280
YLCKEKKKTE
290
KSLTYYTNLQ
300
VKTGQRTLIN
310
PKPCGQFCCC
320
EVLGCEWEDA
330
ISYYTRMKDR
340
LLERITEEER
350
HVQDQPLGMA
360
FVTFQEKSMA
370
TYILKDFNAC
380
KCQSLQCKGE
390
PQPSSHSREL
400
YTSKWTVTFA
410
ADPEDICWKN
420
LSIQGLRWWL
430
QWLGINFTLF
440
LGLFFLTTPS
450
IILSTMDKFN
460
VTKPIHALNN
470
PIISQFFPTL
480
LLWSFSALLP
490
SIVYYSTLLE
500
SHWTKSGENQ
510
IMMTKVYIFL
520
IFMVLILPSL
530
GLTSLDFFFR
540
WLFDKTSSEA
550
SIRLECVFLP
560
DQGAFFVNYV
570
IASAFIGNGM
580
ELLRLPGLIL
590
YTFRMIMAKT
600
AADRRNVKQN
610
QAFQYEFGAM
620
YAWMLCVFTV
630
IVAYSITCPI
640
IAPFGLIYIL
650
LKHMVDRHNL
660
YFVYLPAKLE
670
KGIHFAAVNQ
680
ALAAPILCLF
690
WLYFFSFLRL
700
GMKAPATLFT
710
FLVLLLTILV
720
CLAHTCFGCF
730
KHLSPLNYKT
740
EEPASDKGSE
750
AEAHMPPPFT
760
PYVPRILNGL
770
ASERTALSPQ
780
QQQQQTYGAI
790
HNISGTIPGQ
800
CLAQSATGSV
AAAPQEA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0034451 |
centriolar satellite |
| Cellular Component |
GO:0031901 |
early endosome membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005765 |
lysosomal membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0035579 |
specific granule membrane |
| Cellular Component |
GO:0070821 |
tertiary granule membrane |
| Molecular Function |
GO:0005227 |
calcium-activated cation channel activity |
| Molecular Function |
GO:0008381 |
mechanosensitive monoatomic ion channel activity |
| Molecular Function |
GO:0003676 |
nucleic acid binding |
| Molecular Function |
GO:1990760 |
osmolarity-sensing monoatomic cation channel activity |
| Biological Process |
GO:0007040 |
lysosome organization |
| Biological Process |
GO:0160069 |
surfactant secretion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.