Search Results
Overview
| Uniprot ID | O94888 |
|---|---|
| Protein Name | UBX domain-containing protein 7 |
| Gene Name | UBXN7 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 134 | NGGAIDKKLTTLADL |
| 84 | VRAPIPQKQEILVEP |
| 99 | EPLFGAPKRRRPARS |
Function
Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates
Protein Sequence
10
MAAHGGSAAS
20
SALKGLIQQF
30
TTITGASESV
40
GKHMLEACNN
50
NLEMAVTMFL
60
DGGGIAEEPS
70
TSSASVSTVR
80
PHTEEEVRAP
90
IPQKQEILVE
100
PEPLFGAPKR
110
RRPARSIFDG
120
FRDFQTETIR
130
QEQELRNGGA
140
IDKKLTTLAD
150
LFRPPIDLMH
160
KGSFETAKEC
170
GQMQNKWLMI
180
NIQNVQDFAC
190
QCLNRDVWSN
200
EAVKNIIREH
210
FIFWQVYHDS
220
EEGQRYIQFY
230
KLGDFPYVSI
240
LDPRTGQKLV
250
EWHQLDVSSF
260
LDQVTGFLGE
270
HGQLDGLSSS
280
PPKKCARSES
290
LIDASEDSQL
300
EAAIRASLQE
310
THFDSTQTKQ
320
DSRSDEESES
330
ELFSGSEEFI
340
SVCGSDEEEE
350
VENLAKSRKS
360
PHKDLGHRKE
370
ENRRPLTEPP
380
VRTDPGTATN
390
HQGLPAVDSE
400
ILEMPPEKAD
410
GVVEGIDVNG
420
PKAQLMLRYP
430
DGKREQITLP
440
EQAKLLALVK
450
HVQSKGYPNE
460
RFELLTNFPR
470
RKLSHLDYDI
480
TLQEAGLCPQ
ETVFVQERN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex |
| Molecular Function | GO:0043130 | ubiquitin binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.